PHYLOGENY OF THE INSULIN-LIKE GROWTH-FACTORS (IGFS) AND RECEPTORS - A MOLECULAR APPROACH
PHYLOGENY OF THE INSULIN-LIKE GROWTH-FACTORS (IGFS) AND RECEPTORS - A MOLECULAR APPROACH
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DOI：
10.1002/mrd.1080350403
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发表时间：
1993-08-01
影响因子：
2.5
通讯作者：
ROBERTS, CT
中科院分区：
文献类型：
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作者：
LEROITH, D;KAVSAN, VM;ROBERTS, CT
IGFs（IGF-I和IGF-II）对哺乳动物的正常生长和发育至关重要。它们的作用主要通过与I型IGF受体（IGF-I受体）（一种跨膜酪氨酸激酶）的相互作用介导。配体和IGF-I受体在结构上分别与胰岛素和胰岛素受体相关。对进化保守性的分析经常提供对分子（如激素及其受体）的重要区域的见解。胰岛素和IGFs的基因已经在许多脊椎动物物种中得到了部分表征，这些脊椎动物物种在进化上从人类延伸到鱼类。编码成熟胰岛素和IGF肽的外显子的序列在脊椎动物物种中高度保守，并且在起源可追溯至多达5.5亿年的物种中发现IGF-I样分子。胰岛素受体在脊椎动物物种中也是高度保守的，并且在果蝇中已经表征了胰岛素受体样分子。相反，IGF-I受体仅在哺乳动物物种中得到表征，并在非洲爪蟾中进行了部分研究，其中酪氨酸激酶结构域高度保守。目前正在进行研究，以更详细地分析编码这一重要的生长因子家族的基因的调节以及基因产物本身的结构/功能关系。(C)1993年Wiley-Liss，Inc.*
The IGFs (IGF-I and IGF-II) are essential for normal mammalian growth and development. Their actions are mediated primarily by their interactions with the type I IGF receptor (IGF-I receptor), a transmembrane tyrosine kinase. The ligands and the IGF-I receptor are structurally related to insulin and to the insulin receptor, respectively. Analysis of evolutionary conservation has often provided insights into essential regions of molecules such as hormones and their receptors. The genes for insulin and IGFs have been partially characterized in a number of vertebrate species extending evolutionarily from humans as far back as fish. The sequences of the exons encoding the mature insulin and IGF peptides are highly conserved among vertebrate species, and IGF-I-like molecules are found in species whose origins extend back as much as 550 million years. The insulin receptor is also highly conserved in vertebrate species, and an insulin-receptor-like molecule has been characterized in Drosophila. In contrast, IGF-I receptors have only been characterized in mammalian species and partially studied in Xenopus, in which the tyrosine kinase domain is highly conserved. Studies are presently being undertaken to analyze in more detail the regulation of the genes encoding this important family of growth factors and the structure/function relationships in the gene products themselves. (C) 1993 Wiley-Liss, Inc.*