Bisphenol A, an endocrine-disrupting chemical, and brain development
Bisphenol A, an endocrine-disrupting chemical, and brain development
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DOI：
10.1111/j.1440-1789.2011.01287.x
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发表时间：
2012-08-01
期刊：
影响因子：
2.3
通讯作者：
Fushiki, Shinji
中科院分区：
文献类型：
--
作者：
Itoh, Kyoko;Yaoi, Takeshi;Fushiki, Shinji
双酚A（BPA）是一种内分泌干扰化学品，广泛应用于各个行业和牙科领域。因此，人类接触BPA的增加使我们对生殖和大脑发育的潜在有害影响产生了一些担忧。这篇综述的重点是产前和哺乳期暴露于低剂量BPA对小鼠大脑发育的影响。我们证明，产前暴露于BPA影响胎鼠新皮质发育，通过加速胚胎早期神经元分化/迁移，这与上调和下调对大脑发育至关重要的基因，包括基本的螺旋-环-螺旋转录因子。在成年小鼠的大脑中，暴露于BPA的组中持续存在异常的新皮层结构和异常的皮质丘脑投射。在功能上，BPA暴露扰乱了小鼠的行为，伴随着神经递质系统的破坏，包括单胺，在出生后的发育期和成年小鼠。我们还证明了启动子相关CpG岛的表观遗传学改变可能是暴露于BPA后对大脑发育的一些影响的基础。
Bisphenol A (BPA) is an endocrine-disrupting chemical, widely used in various industries and the field of dentistry. The consequent increase in BPA exposure among humans has led us to some concerns regarding the potential deleterious effects on reproduction and brain development. The emphasis of this review is on the effects of prenatal and lactational exposure to low doses of BPA on brain development in mice. We demonstrated that prenatal exposure to BPA affected fetal murine neocortical development by accelerating neuronal differentiation/migration during the early embryonic stage, which was associated with up- and down-regulation of the genes critical for brain development, including the basic helix-loop-helix transcription factors. In the adult mice brains, both abnormal neocortical architecture and abnormal corticothalamic projections persisted in the group exposed to the BPA. Functionally, BPA exposure disturbed murine behavior, accompanied with a disrupted neurotransmitter system, including monoamines, in the postnatal development period and in adult mice. We also demonstrated that epigenetic alterations in promoter-associated CpG islands might underlie some of the effects on brain development after exposure to BPA.