Six insecticidal isoryanodane diterpenoids from the bark and twigs of Itoa orientalis
Six insecticidal isoryanodane diterpenoids from the bark and twigs of Itoa orientalis
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DOI：
10.1016/j.tet.2008.04.022
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发表时间：
2008-06-09
期刊：
影响因子：
2.1
通讯作者：
Tu, Peng-Fei
中科院分区：
文献类型：
--
作者：
Chai, Xing-Yun;Bai, Chang-Cai;Tu, Peng-Fei
从Itoa orientalis 的树皮和嫩枝中分离出四种稀有的异梁烷二萜，即醇A-D (1-4) 和两种异梁烷苷(5 和6)。通过NMR和MS技术确定了它们的结构，并且通过单晶X射线衍射证实了1的结构。这6种二萜类化合物对甜菜夜蛾具有明显的杀虫活性，1和2的LC(50)分别为28.62 ppm和52.76 ppm。在抗炎实验中，化合物1和4-6表现出抗COX-2活性，10μm时的抑制率为54.7-78.3%。 (C) 2008 Elsevier Ltd. 保留所有权利。
Four rare isoryanodane diterpenoids namely itols A-D (1-4) and two isoryanosdane glucosides (5 and 6) were isolated from the bark and twigs of Itoa orientalis. Their structures were determined by NMR and MS techniques and the Structure of 1 was confirmed by a single-crystal X-ray diffraction. These six diterpenoids obviously showed insecticidal activity against Spodoptera exigua, with LC(50) 28.62 ppm for 1 and 52.76 ppm for 2, respectively. In anti-inflammatory assay, compounds 1 and 4-6 showed anti-COX-2 activity, with inhibitory rates of 54.7-78.3% at 10 mu m. (C) 2008 Elsevier Ltd. All rights reserved.