Diagnostic value of interferon gamma release assays combined__with IL-6 detection in active pulmonary tuberculosis
Diagnostic value of interferon gamma release assays combined__with IL-6 detection in active pulmonary tuberculosis
复制标题
干扰素γ释放试验联合IL-6检测对活动性肺结核的诊断价值
DOI：
10.3969/j.issn.1005-8982.2020.10.004
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发表时间：
2020
期刊：
影响因子：
--
通讯作者：
刘银
中科院分区：
文献类型：
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作者：
许敏殷;刘银
目的 探讨干扰素γ释放试验（IGRA）联合白细胞介素 - 6（IL - 6）检测对活动性肺结核的诊断价值。方法 选取2018年6月至2019年6月在我院收治的700例肺结核患者作为研究对象，其中活动性肺结核患者587例，非活动性肺结核患者113例，同期选取100例在我院体检的健康人作为对照。比较三组的IGRA结果及IL - 6水平。采用受试者工作特征（ROC）曲线评估IGRA和血清IL - 6对活动性肺结核的诊断效能。结果 三组血清IL - 6含量及IGRA阳性率差异有统计学意义（P < 0.05），A组高于B组和健康对照组（P < 0.05），B组高于健康对照组（P < 0.05）。根据ROC曲线分析，IGRA诊断活动性肺结核的敏感度和特异度分别为80.92%和70.80%；当IL - 6值为20.24 ng/L时，敏感度和特异度分别为74.79%和83.19%；联合诊断的敏感度和特异度分别为84.33%和85.84%。结论 IGRA和IL - 6对活动性肺结核具有较高的诊断价值，二者联合敏感度和特异度更高，可用于临床活动性肺结核的辅助诊断。
Objective To investigate the diagnostic value of interferon γ release assay (IGRA) combined with.IL-6 detection in active pulmonary tuberculosis. Methods Seven hundred pulmonary tuberculosis patients admitted.to our hospital were selected as the research objects from June 2018 to June 2019, including 587 active pulmonary.tuberculosis patients and 113 non-active pulmonary tuberculosis patients, 100 healthy people who were admitted to.hospital for physical examination in the same period were selected as the control. The results of IGRAs and the level.of IL-6 were compared among the three groups. ROC curve was used to evaluate the diagnostic efficacy of IGRAs.and serum IL - 6 in active pulmonary tuberculosis. Results The difference of serum IL-6 content and IGRAs positive.rate among the three groups was statistically significant (P < 0.05), and A group was higher than B group and healthy.control group (P < 0.05), B group was higher than healthy control group (P < 0.05). The sensitivity and specificity of.IGRA in the diagnosis of active tuberculosis were 80.92% and 70.80%, respectively, according to ROC curve analysis;.when the value of IL-6 was 20.24 ng/L, the sensitivity and specificity were 74.79% and 83.19%, respectively; the sensitivity and specificity of combined diagnosis were 84.33% and 85.84%, respectively. Conclusion IGRA and IL-6 have high diagnostic value for active pulmonary tuberculosis, and their combined sensitivity and specificity are higher, which can be used for the auxiliary diagnosis of active pulmonary tuberculosis in clinic.