Surface Functionalization of Titanium Alloy with miR-29b Nanocapsules To Enhance Bone Regeneration
Surface Functionalization of Titanium Alloy with miR-29b Nanocapsules To Enhance Bone Regeneration
复制标题
miR-29b 纳米胶囊对钛合金进行表面功能化以增强骨再生
DOI：
10.1021/acsami.5b10650
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发表时间：
2016
影响因子：
9.5
通讯作者：
Yang Xianjin
中科院分区：
文献类型：
--
作者：
Meng Yubin;Li Xue;Li Zhaoyang;Liu Chaoyong;Zhao Jin;Wang Jianwei;Liu Yunde;Yuan Xubo;Cui Zhenduo;Yang Xianjin
钛及其合金在过去的30年里被广泛用于骨缺损的修复。然而，钛合金的生物惰性限制了其临床应用，经常采用表面改性的方法来改善其生物和化学性能。近年来，具有成骨能力的microRNA的递送被认为是促进种植体骨再生的一种有前途的工具。在此，我们开发了一种生物可降解涂层来修饰钛表面，以提高成骨生物活性。将先前开发的纳米胶囊作为构建块，然后设计生物活性钛涂层来包裹miR-29b纳米胶囊。该涂层不仅有利于细胞的粘附和生长，而且具有足够的microRNA转染效能和骨诱导潜能，显著增强了生物惰性钛合金表面的骨再生能力。
Titanium and its alloys have been widely used over the past 3 decades as implants for healing bone defects. Nevertheless, the bioinert property of titanium alloy limits its clinical application and surface modification method is frequently performed to improve the biological and chemical properties. Recently, the delivery of microRNA with osteogenesis capability has been recognized as a promising tool to enhance bone regeneration of implants. Here, we developed a biodegradable coating to modify the titanium surface in order to enhance osteogenic bioactivity. The previous developed nanocapsules were used as the building blocks, and then a bioactive titanium coating was designed to entrap the miR-29b nanocapsules. This coating was not only favorable for cell adhesion and growth but also provided sufficient microRNA transfection efficacy and osteoinductive potential, resulting in a significant enhancement of bone regeneration on the surface of bioinert titanium alloy.