Risk of Eating Disorders in Patients With Celiac Disease
Risk of Eating Disorders in Patients With Celiac Disease
复制标题
DOI：
10.1097/mpg.0000000000001648
复制
发表时间：
2018-01-01
影响因子：
2.9
通讯作者：
Salas-Salvado, Jordi
中科院分区：
文献类型：
--
作者：
Babio, Nancy;Alcazar, Mireia;Salas-Salvado, Jordi
目的：已经报道了几例乳糜泻（CD）患者的饮食失调（EDs），表明ED可能是与CD相关的合并症。然而，很少有流行病学研究评估这种潜在的关联。我们的目的是评估诊断为乳糜泻的个体与健康对照组相比发生ed的风险。方法：选取性别、年龄、体质指数相匹配的10 ~ 23岁患者98例，对照组98例。完成了一份关于病史、社会人口学和人体测量特征的问卷。进行了各种ED筛查自我报告测试。结果：研究人群中女孩占61.2%，平均年龄15.33.7岁。乳糜泻患者在所有ED筛查测试中的得分均未显著高于对照组。在超过临床临界值确定有ED风险的个体频率方面，研究组之间没有观察到差异。13岁以上的CD患者与对照组相比，饮食态度测试得分增加2.15分[-系数=2.15 SE 1.04；P=0.04]。结论：尽管在13岁以上的个体中，作为乳糜泻患者与较高的饮食态度测试分数相关，但当使用其他筛查测试时，乳糜泻患者与对照组之间在ED风险方面没有明显差异。需要更多的大样本和前瞻性设计的研究来证实这些发现。
Objectives:Several cases of eating disorders (EDs) have been reported in patients with celiac disease (CD), suggesting that ED could be a comorbidity associated with CD. Few epidemiological studies have, however, assessed this potential association. We aimed to evaluate the risk of EDs in individuals diagnosed with CD in comparison to healthy controls.Methods:A total of 98 cases and 98 controls matched for sex, age, and body mass index between 10 and 23 years old were studied. A questionnaire was completed on medical history and sociodemographic as well as anthropometric characteristics. Various ED screening self-reported tests were administered.Results:A total of 61.2% of the study population were girls with a mean age of 15.33.7 years old. Patients with CD scored nonsignificantly higher on all the ED screening tests than control participants. No differences were observed between study groups in terms of the frequency of individuals who exceeded the clinical cutoff identifying those at risk of ED. Patients with CD above 13 years old were associated with a 2.15-point increase in the Eating Attitude Test score compared with controls [-coefficient=2.15 SE 1.04; P=0.04] after adjusting for various confounders.Conclusions:Although being a patient with CD was associated with a significantly higher Eating Attitude Test score in individuals older than 13 years old, no clear differences were observed between individuals with CD and controls in terms of risk of ED when other screening tests were used. More studies with larger samples and prospective designs are warranted to confirm these findings.