Self-assembling diblock copolymers of poly[N-(2-hydroxypropyl)methacrylamide] and a beta-sheet peptide.
Self-assembling diblock copolymers of poly[N-(2-hydroxypropyl)methacrylamide] and a beta-sheet peptide.
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DOI：
10.1002/mabi.200800193
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发表时间：
2009-01-09
影响因子：
4.6
通讯作者：
Kopecek J
中科院分区：
文献类型：
--
作者：
Radu LC;Yang J;Kopecek J
研究了由聚（HPMA）和β折叠肽P11（CH 3CO-QQRFQWQFEQQ-NH 2）组成的杂化嵌段共聚物的自组装行为。通过巯基-马来酰亚胺偶联反应，将半遥爪聚（HPMA）-SH与马来酰亚胺修饰的β-折叠肽偶联，合成了共聚物。正如预期的那样，CD和CR结合研究表明，肽嵌段将其β-折叠结构排列强加于二嵌段共聚物的结构上。TEM和AFM证实了肽和共聚物具有自组装成纤维的能力。
The self-assembly of hybrid diblock copolymers composed of poly(HPMA) and β-sheet peptide P11 (CH3CO-QQRFQWQFEQQ-NH2) blocks was investigated. Copolymers were synthesized via thiol-maleimide coupling reaction, by conjugation of semitelechelic poly(HPMA)-SH with maleimide-modified β-sheet peptide. As expected, CD and CR binding studies showed that the peptide block imposed its β-sheet structural arrangement on the structure of diblock copolymers. TEM and AFM proved that peptide and these copolymers had the ability to self-assemble into fibrils.