One-pot synthesis of PEGylated plasmonic MoO3-x hollow nanospheres for photoacoustic imaging guided chemo-photothermal combinational therapy of cancer
One-pot synthesis of PEGylated plasmonic MoO3-x hollow nanospheres for photoacoustic imaging guided chemo-photothermal combinational therapy of cancer
复制标题
一锅合成聚乙二醇化等离子体MoO3-x空心纳米球用于光声成像引导的癌症化学光热联合治疗
DOI：
10.1016/j.biomaterials.2015.10.048
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发表时间：
2016-01-01
期刊：
影响因子：
14
通讯作者：
Zhao, Yuliang
中科院分区：
文献类型：
--
作者：
Bao, Tao;Yin, Wenyan;Zhao, Yuliang
等离子体纳米材料作为具有成像、载药和光热治疗（FIT）功能的按需治疗纳米剂的工程设计对癌症的治疗具有深远的影响。本文首先建立了一种简便的无模板水热法合成聚乙二醇（PEG-MoO3-x HNSs）功能化等离子体缺氧氧化钼空心纳米球。制备的PEG-MoO3-x HNSs不仅具有良好的生物相容性，而且在近红外（NIR）区域具有明显的局部表面等离子体共振（LSPR）吸收。特别是，由于其固有的介孔性质和808 nm近红外激光照射下有效的光热转换效率，PEG-MoO3-x HNSs可以作为pH/近红外激光双响应的喜树碱（CPT）药物递送纳米平台，用于化疗和肿瘤细胞的PTT。与化疗或单独使用PTT相比，对胰腺（PANC-1）荷瘤小鼠的协同治疗效果显著提高。除了用于给药外，PEG-MoO3-x HNSs还可以作为光声成像的有效造影剂，由于其高近红外吸收，使其成为纳米医学领域光声成像引导化学-光热联合癌症治疗的有效纳米造影剂。(c) 2015 Elsevier Ltd.版权所有。
Engineering design of plasmonic nanomaterials as on-demand theranostic nanoagents with imaging, drug carrier, and photothermal therapy (FIT) functions have profound impact on treatment of cancer. Here, a facile 'one-pot' template-free hydrothermal route was firstly developed for synthesis of plasmonic oxygen deficiency molybdenum oxide hollow nanospheres functionalized by poly(ethylene glycol) (PEG-MoO3-x HNSs). The as-prepared PEG-MoO3-x HNSs not only have good biocompatibility but also exhibit obvious localized surface plasmon resonance (LSPR) absorption in the near-infrared (NIR) region. Especially, due to its intrinsic mesoporous properties and effective photothermal conversion efficiency upon 808-nm NIR laser irradiation, the PEG-MoO3-x HNSs can be applied as a pH/NIR laser dual-responsive camptothecin (CPT) drug delivery nanoplatform for chemotherapy as well as PTT to cancer cells. A remarkably improved synergistic therapeutic effect to pancreatic (PANC-1) tumor-bearing mice was obtained compared to the result of chemotherapy or PTT alone. Apart from its application for drug delivery, the PEG-MoO3-x HNSs can also be employed as an effective contrast nanoagent for photoacoustic (PAT) imaging because of its high NIR absorption, making it promising as a theranostic nanoagent for PAT imaging-guided chemo-photothermal combinational cancer therapy in the nanomedicine field. (c) 2015 Elsevier Ltd. All rights reserved.