Binding of CXCL8/IL-8 to Mycobacterium tuberculosis Modulates the Innate Immune Response.
Binding of CXCL8/IL-8 to Mycobacterium tuberculosis Modulates the Innate Immune Response.
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DOI：
10.1155/2015/124762
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发表时间：
2015
影响因子：
4.6
通讯作者：
Kurdowska AK
中科院分区：
文献类型：
--
作者：
Krupa A;Fol M;Dziadek BR;Kepka E;Wojciechowska D;Brzostek A;Torzewska A;Dziadek J;Baughman RP;Griffith D;Kurdowska AK
白细胞介素-8（IL-8）与包括结核病（TB）在内的多种人类呼吸道疾病的发病机制有关。重要的是，与本报告的目的直接相关的是，相当多的发现表明IL-8的存在可能对宿主有益。IL-8可能有助于在结核分枝杆菌感染期间建立足够的应答（M.然而，其潜在机制在很大程度上仍不清楚。我们研究的主要目的是研究IL-8对结核病患者通常引发的炎症过程的贡献。我们首次证明IL-8可以直接与结核杆菌结合。我们还证实了IL-8与M. TB分子导致白细胞（嗜中性粒细胞和巨噬细胞）吞噬和杀死这些杆菌的能力增强。此外，我们已经表明TB患者血液中存在的显著量的IL-8与红细胞相关。最后，我们注意到IL-8是负责募集T淋巴细胞（CD 3+、CD 4+和CD 8 + T细胞）的主要趋化因子。总之，我们的数据表明IL-8与M.结核病分子可能改变并可能增强结核病患者的先天免疫反应。
Interleukin-8 (IL-8) has been implicated in the pathogenesis of several human respiratory diseases, including tuberculosis (TB). Importantly and in direct relevance to the objectives of this report quite a few findings suggest that the presence of IL-8 may be beneficial for the host. IL-8 may aid with mounting an adequate response during infection with Mycobacterium tuberculosis (M. tb); however, the underlying mechanism remains largely unknown. The major goal of our study was to investigate the contribution of IL-8 to the inflammatory processes that are typically elicited in patients with TB. We have shown for the first time that IL-8 can directly bind to tubercle bacilli. We have also demonstrated that association of IL-8 with M. tb molecules leads to the augmentation of the ability of leukocytes (neutrophils and macrophages) to phagocyte and kill these bacilli. In addition, we have shown that significant amount of IL-8 present in the blood of TB patients associates with erythrocytes. Finally, we have noted that IL-8 is the major chemokine responsible for recruiting T lymphocytes (CD3+, CD4+, and CD8+ T cells). In summary, our data suggest that the association of IL-8 with M. tb molecules may modify and possibly enhance the innate immune response in patients with TB.