Benign clear (sugar) cell tumor of the lung with CD1a expression
Benign clear (sugar) cell tumor of the lung with CD1a expression
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DOI：
10.1111/j.1440-1827.2006.01988.x
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发表时间：
2006-08-01
影响因子：
2.2
通讯作者：
Hayashi, Kazuhiko
中科院分区：
文献类型：
--
作者：
Adachi, Yoshin;Kitamura, Yukisato;Hayashi, Kazuhiko
本文报道一例 60 岁男性肺部良性透明细胞肿瘤病例。胸部X线和CT检查发现左肺下叶有一密度均匀、边缘清晰的异常结节。切除肿瘤大小13mm，边界清楚，切面灰白色。组织学检查显示多角形肿瘤细胞呈弥漫性生长模式，细胞核凹陷且多形性，细胞质清晰丰富，细胞边界清晰，周围有薄壁血管间隙和窦状血管。 PAS 染色证明透明细胞质含有大量糖原颗粒。在本病例中，S-100蛋白、HMB-45、神经元特异性烯醇化酶、组织蛋白酶B和黑色素A具有局灶性免疫反应性，这与报道的良性透明细胞肿瘤的免疫组织化学染色模式一致。根据这些发现，肿瘤被诊断为肺部良性透明细胞肿瘤。尽管大多数透明细胞肿瘤被认为属于血管周围上皮样细胞分化的肿瘤家族（PEComas），但肺良性透明细胞肿瘤的组织发生仍不清楚。该肿瘤中 CD1a 表达的首次报告可能为其组织发生和诊断提供新的见解。
Reported herein is a case of benign clear cell tumor of the lung in a 60-year-old man. Chest X-ray and CT examination revealed an abnormal nodule with homogenous density and a clear margin in the lower lobe of the left lung. The resected tumor was 13 mm in size, well-circumscribed and was graysh-white on cut surface. Histological examination showed a diffuse growth pattern of polygonal tumor cells with indented and pleomorphic nuclei, and clear abundant cytoplasm with a distinct cell border surrounded by thin-walled vascular spaces and sinusoid-type vessels. The clear cytoplasm contained numerous glycogen granules as demonstrated by PAS staining. In the present case there was focal immunoreactivity for S-100 protein, HMB-45, neuron-specific enolase, cathepsin B and melan A, which are consistent with reported immunohistochemical staining patterns of benign clear cell tumor. Based on these findings, the tumor was diagnosed as a benign clear cell tumor of the lung. Although most clear cell tumors are considered to belong to the family of neoplasms with perivascular epithelioid cell differentiation (PEComas), histogenesis of benign clear cell tumor of the lung has remained unclear. This first report of CD1a expression in this tumor might provide a new insight into its histogenesis and diagnosis.