High progesterone receptor expression in prostate cancer is associated with clinical failure.
High progesterone receptor expression in prostate cancer is associated with clinical failure.
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DOI：
10.1371/journal.pone.0116691
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发表时间：
2015
期刊：
影响因子：
3.7
通讯作者：
Richardsen E
中科院分区：
文献类型：
--
作者：
Grindstad T;Andersen S;Al-Saad S;Donnem T;Kiselev Y;Nordahl Melbø-Jørgensen C;Skjefstad K;Busund LT;Bremnes RM;Richardsen E
前列腺癌是一种高度异质性的疾病，是发达国家死亡率的主要原因之一。前列腺癌患者的特异性预后和预测标志物仍然缺乏。雄激素和前列腺癌的发展之间的因果关系通常被认为是生物学上合理的，但雄激素不是前列腺癌发生的复杂性的唯一效应。本研究的目的是评估孕激素受体在T1- 3 N 0前列腺癌患者行前列腺切除术的肿瘤组织中的预后意义。构建了535例前列腺癌患者的组织芯片。从每个切除标本中提取肿瘤细胞和肿瘤间质组织的重复核心。免疫组化法检测孕激素受体的原位表达。在单变量分析中，孕激素受体的高肿瘤细胞密度（p = 0.006）和高肿瘤基质细胞密度水平（p = 0.045）均与肿瘤进展和临床失败显著相关。在多变量分析中，肿瘤细胞中的孕激素受体表达是临床失败的独立阴性预后因素（HR：2.5，95% CI：1.2-5.2，p = 0.012）。前列腺癌肿瘤细胞中的高孕酮受体密度是临床失败的独立负性预后因素。
Prostate cancer is a highly heterogeneous disease and one of the leading causes of mortality in developed countries. Specific prognostic and predictive markers for prostate cancer patients are still lacking. A causal relationship between androgens and the development of prostate cancer is generally considered biologically plausible, but androgens are not the sole effector in the complexity of prostate carcinogenesis. The aim of this study was to evaluate the prognostic significance of progesterone receptor in tumor tissue of T1-3N0 prostate cancer patients undergoing prostatectomy. Tissue microarrays from 535 patients with prostate cancer were constructed. Duplicate cores of tumor cells and tumor stromal tissue from each resected specimen were extracted. Immunohistochemistry was used to evaluate the in-situ expression of progesterone receptor. In univariate analyses, high tumor cell density (p = 0.006) and high tumor stromal cell density level (p = 0.045) of progesterone receptor were both significantly associated with tumor progression and clinical failure. In multivariate analysis, progesterone receptor expression in tumor cells was an independent negative prognostic factor for clinical failure (HR: 2.5, 95% CI: 1.2–5.2, p = 0.012). High progesterone receptor density in tumor cells of the prostate cancer tumor is an independent negative prognostic factor for clinical failure.
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影响因子：
2
作者：
Andersen, Sigve;Richardsen, Elin;Bremnes, Roy M.
通讯作者：
Bremnes, Roy M.
影响因子：
5.7
作者：
Dohi, Osamu;Hatori, Masahito;Sasano, Hironobu
通讯作者：
Sasano, Hironobu
影响因子：
4.8
作者：
CASTAGNETTA, LA;MICELI, MD;CARRUBA, G
通讯作者：
CARRUBA, G
影响因子：
82.9
作者：
Kononen, J;Bubendorf, L;Kallioniemi, OP
通讯作者：
Kallioniemi, OP
影响因子：
7.3
作者：
Hobisch, A;Hittmair, A;Culig, Z
通讯作者：
Culig, Z