BIOMECHANICS OF GLUTARALDEHYDE-TREATED PORCINE AORTIC ROOTS AND VALVES - AN INVESTIGATION OF THE EFFECT OF PREDILATION OF THE ELASTIC AORTIC ROOT
BIOMECHANICS OF GLUTARALDEHYDE-TREATED PORCINE AORTIC ROOTS AND VALVES - AN INVESTIGATION OF THE EFFECT OF PREDILATION OF THE ELASTIC AORTIC ROOT
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DOI：
10.1016/s0022-5223(94)70145-8
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发表时间：
1994-12-01
影响因子：
6
通讯作者：
WATTERSON, K
中科院分区：
文献类型：
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作者：
LOCKIE, KJ;FISHER, J;WATTERSON, K
新鲜猪主动脉根和瓣膜的生物力学和功能进行了比较，与那些戊二醛处理的根准备在传统的方式没有弹性的主动脉根的扩张和戊二醛处理的根准备在固定过程中永久预扩张。戊二醛处理的主动脉壁的可伸展性明显低于新鲜壁，在120 mm Hg压力下，平均扩张仅为6%，而新鲜根部为45%。在固定过程中，主动脉根部的永久预扩张允许固定根部的总扩张在120 mm Hg压力下增加至19%。新鲜牙根和瓣膜的有效瓣口面积显著大于固定牙根和瓣膜的有效瓣口面积，永久性预扩张固定产生的瓣口面积显著大于传统固定。发现永久预扩张后固定瓣膜的开放瓣叶弯曲变形低于标准固定瓣膜。戊二醛处理的猪根和瓣膜不能再现新鲜根的生物力学和功能，因为固定的主动脉钉的可伸展性降低。固定过程中的永久性预扩张有助于部分克服固定根部的缺点，产生比标准固定瓣膜更好的功能。
The biomechanics and function of fresh porcine aortic roots and valves have been compared, with those of glutaraldehyde-treated roots prepared in a conventional manner without dilation of the elastic aortic root and with glutaraldehyde-treated roots prepared with permanent predilation during fixation. The glutaraldehyde-treated aortic walls were significantly less extensible than fresh walls, with a mean dilation of only 6% compared with 45% for the fresh root at 120 mm Hg pressure, Permanent predilation of the aortic root during fixation allowed the total dilation of the fixed root to be increased to 19% at 120 mm Hg pressure. The effective orifice area of the fresh root and valve was significantly greater than those of the fixed roots and valves, with permanent predilation fixation producing a significantly greater orifice area than conventional fixation. The open-leaflet bending deformations were found to be lower in the valves fixed after permanent predilation than in the standard fixed valves. The glutaraldehyde-treated porcine root and valve does not reproduce the biomechanics and function of the fresh root, because of the reduced extensibility of the fixed aortic nail. Permanent predilation during fixation helps to partially overcome the shortcomings of the fixed root, producing better function than a standard fixed valve.