Neurologic complications of cervical cancer. A review of 2261 cases
Neurologic complications of cervical cancer. A review of 2261 cases
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DOI：
10.1002/1097-0142(19890901)64:5
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发表时间：
1989-09
期刊：
影响因子：
6.2
通讯作者：
T. Saphner;H. Gallion;J. van Nagell;R. Kryscio;R. Patchell
中科院分区：
文献类型：
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作者：
T. Saphner;H. Gallion;J. van Nagell;R. Kryscio;R. Patchell
作者回顾了2261例经组织学证实的宫颈癌患者的记录。在1042例原位癌患者中，发生了4例神经系统并发症（0.4%），包括3例中风和1例癫痫发作。神经系统并发症均与宫颈癌无关。在1219例国际妇产科联盟（FIGO）I期或以上疾病患者中，发生了99例神经系统并发症（8%）。转移性神经系统并发症的发生率是非转移性神经系统并发症的两倍，包括腰骶神经丛病（50例患者）、周围神经压迫（8例患者）、脊髓压迫（2例患者）和脑转移（6例患者）。非转移性神经系统并发症发生率较低，包括卒中（11例患者）、脑病（3例患者）、感染并发症（2例患者）、治疗效果（6例患者）和癫痫发作（11例患者）。总之，神经系统并发症在宫颈癌中是罕见的，在0期疾病中几乎不存在。转移性神经系统并发症比非转移性并发症更常见，腹膜后淋巴结转移引起的腰骶神经丛病变是最常见的神经系统并发症。
The authors reviewed the records of 2261 patients with histologically proven cervical cancer. Among the 1042 patients with carcinoma in situ, four neurologic complications occurred (0.4%), including three strokes and one seizure. None of the neurologic complications were related to cervical cancer. Among the 1219 patients with International Federation of Gynecology and Obstetrics (FIGO) Stage I or greater disease, 99 neurologic complications occurred (8%). Metastatic neurologic complications were twice as common as nonmetastatic neurologic complications and included lumbosacral plexopathy (50 patients), peripheral nerve compressions (eight patients), spinal cord compressions (two patients), and brain metastases (six patients). Nonmetastatic neurologic complications were less frequent and included stroke (11 patients), encephalopathies (three patients), infectious complications (two patients), effects of therapy (six patients), and seizures (11 patients). In conclusion, neurologic complications are rare in cervical cancer and virtually nonexistant in Stage 0 disease. Metastatic neurologic complications were more common than nonmetastatic complications and lumbosacral plexopathy caused by retroperitoneal lymph node metastases was the most common neurologic complication.