Does the Intestinal Microbiota Explain Differences in the Epidemiology of Liver Disease between East and West?
Does the Intestinal Microbiota Explain Differences in the Epidemiology of Liver Disease between East and West?
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DOI：
10.1159/000443196
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发表时间：
2016-04
影响因子：
--
通讯作者：
Schnabl B
中科院分区：
文献类型：
--
作者：
Nakamoto N;Schnabl B
细菌群落的变化与许多疾病的发病机制有关，包括炎症性肠病和肝病。菌群失调可引起肠道炎症，导致肠道通透性增加和细菌移位。大多数慢性肝病与细菌移位有关，导致或增强肝脏中的炎症反应。如果没有额外的肝脏损伤，肠道炎症和肠道屏障功能障碍不足以引起肝脏疾病。在这篇文章中，作者总结了东西方国家肠道微生物群组成的差异。作者特别讨论了微生物群组成的差异是否可以解释亚洲和欧洲/美国肝病的流行病学差异。
Changes in bacterial communities are associated with the pathogenesis of many diseases including inflammatory bowel disease and liver disease. Dysbiosis can induce intestinal inflammation resulting in increased intestinal permeability and bacterial translocation. The majority of chronic liver diseases are associated with bacterial translocation resulting in or enhancing an inflammatory response in the liver. Intestinal inflammation and a dysfunctional intestinal barrier are not sufficient to cause liver disease in the absence of an additional liver insult. In this article, the authors summarize differences in intestinal microbiota composition between Eastern and Western countries. The authors specifically discuss whether differences in microbiota composition could explain the epidemiological differences in liver disease found in Asia and Europe/the USA.