Molecular genetics of the stress-responsive adrenocortical axis.
Molecular genetics of the stress-responsive adrenocortical axis.
复制标题
应激反应性肾上腺皮质轴的分子遗传学。
DOI：
10.1080/07853890701724863
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发表时间：
2008
影响因子：
4.4
通讯作者：
Redei,EvaE
中科院分区：
文献类型：
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作者：
Redei,EvaE
应激反应性肾上腺皮质功能是个体与其环境之间发生相互作用时对级联事件的最终生理反应。糖皮质激素的产生是对体内平衡紊乱的反应，是恢复体内平衡所需能量的必需品。遗传因素导致基础和刺激血浆糖皮质激素水平的个体差异，也导致肾上腺质量增加，对长期肾上腺刺激作出反应。本文简要介绍了肾上腺皮质轴的调节，总结了迄今为止在人类和模式生物中进行的连锁研究，并讨论了可能有助于变异的潜在候选基因。糖皮质激素应激反应的个体差异的重要性，特别注意其在最近肥胖症爆发和代谢综合征X的患病率中的潜在作用，进行了评论。
Stress‐responsive adrenocortical function is the final physiological response to the cascade of events that occurs when the interaction between individuals and their environment takes place. Glucocorticoids are produced in response to perturbance of homeostasis and are necessary for the energy required to restore this homeostasis. Genetics contributes to the individual variation in basal and stimulated plasma glucocorticoid levels and also to adrenal gland mass that increases in response to prolonged adrenal stimulation. This review briefly describes regulation of the adrenocortical axis, summarizes the linkage studies carried out so far in humans and in model organisms, and discusses the potential candidate genes that might contribute to the variation. The significance of individual variations in the glucocorticoid stress‐responsiveness, with particular attention to their potential role in the recent explosion of obesity and the prevalence of metabolic syndrome X, is commented upon.