Evolutionarily conserved mechanisms for the selection and maintenance of behavioural activity
Evolutionarily conserved mechanisms for the selection and maintenance of behavioural activity
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DOI：
10.1098/rstb.2015.0053
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发表时间：
2015-12-19
影响因子：
6.3
通讯作者：
Hirth, Frank
中科院分区：
文献类型：
--
作者：
Fiore, Vincenzo G.;Dolan, Raymond J.;Hirth, Frank
生存和繁殖需要选择适应性的行为剧目。这种选择表现为依赖于进化的神经系统回路的遗传学获得的活动。洛伦茨和丁伯根已经假设，遗传行为及其可靠的表现是由基因决定的程序所指定的。在这里，我们比较了昆虫中央复合体和脊椎动物基底神经节的功能解剖，以说明它们在介导选择和维持适应行为中的作用。比较分析表明，中央复合体和基底神经节电路共享功能集成的神经元集群内的可比谱系关系。这些簇是由遗传机制指定的，该机制将出生时间和顺序与它们的神经元身份和功能联系起来。它们随后的连接和相关功能的特征在于类似的机制，通过吸引子状态实现降维和过渡，从而空间组织的平行投影回路整合并传达选择和维持行为活动的感觉运动表征。在这两个类群中，这些神经系统都受到多巴胺信号的调节，多巴胺信号也介导了记忆样过程。中央复合体和基底神经节之间的相似性的多样性表明进化保守的计算机制的行动选择。我们推测，这些可能起源于昆虫和脊椎动物最后的共同祖先大脑中的祖先接地模式电路。
Survival and reproduction entail the selection of adaptive behavioural repertoires. This selection manifests as phylogenetically acquired activities that depend on evolved nervous system circuitries. Lorenz and Tinbergen already postulated that heritable behaviours and their reliable performance are specified by genetically determined programs. Here we compare the functional anatomy of the insect central complex and vertebrate basal ganglia to illustrate their role in mediating selection and maintenance of adaptive behaviours. Comparative analyses reveal that central complex and basal ganglia circuitries share comparable lineage relationships within clusters of functionally integrated neurons. These clusters are specified by genetic mechanisms that link birth time and order to their neuronal identities and functions. Their subsequent connections and associated functions are characterized by similar mechanisms that implement dimensionality reduction and transition through attractor states, whereby spatially organized parallel-projecting loops integrate and convey sensorimotor representations that select and maintain behavioural activity. In both taxa, these neural systems are modulated by dopamine signalling that also mediates memory-like processes. The multiplicity of similarities between central complex and basal ganglia suggests evolutionarily conserved computational mechanisms for action selection. We speculate that these may have originated from ancestral ground pattern circuitries present in the brain of the last common ancestor of insects and vertebrates.