Programmable polymer-DNA hydrogels with dual input and multiscale responses.
Programmable polymer-DNA hydrogels with dual input and multiscale responses.
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DOI：
10.1039/c3bm60126a
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发表时间：
2014-02
影响因子：
6.6
通讯作者：
Giovanna Sicilia;Christine Grainger-Boultby;Nora Francini;J. Magnusson;A. Saeed;F. Fernández-Trillo;Sebastian G. Spain;C. Alexander
中科院分区：
文献类型：
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作者：
Giovanna Sicilia;Christine Grainger-Boultby;Nora Francini;J. Magnusson;A. Saeed;F. Fernández-Trillo;Sebastian G. Spain;C. Alexander
已经合成了组合可切换的聚合物-DNA水凝胶，以响应特异性寡核苷酸识别信号和非特异性但生物相关的环境触发。所述水凝胶表现出可通过与互补DNA链相互作用和/或还原来调节的流变性质。此外，单独和组合的寡核苷酸识别和还原反应允许控制凝胶中的孔径，从而实现从纳米到微米尺度的物体的可编程释放和运输。
Combination switchable polymer-DNA hydrogels have been synthesized to respond to both a specific oligonucleotide recognition signal and a non-specific but biorelevant environmental trigger. The hydrogels exhibit rheological properties that can be modulated through interaction with complementary DNA strands and/or reduction. Furthermore, individual and combined oligonucleotide recognition and reduction responses allow control over pore sizes in the gel, enabling programmable release and transport of objects ranging from the nano- to micro-scale.