Daily aerobic exercise improves reactive hyperemia in patients with essential hypertension
Daily aerobic exercise improves reactive hyperemia in patients with essential hypertension
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DOI：
10.1161/01.hyp.33.1.591
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发表时间：
1999-01-01
期刊：
影响因子：
8.3
通讯作者：
Oshima, T
中科院分区：
文献类型：
--
作者：
Higashi, Y;Sasaki, S;Oshima, T
长期有氧运动对原发性高血压患者内皮功能的影响尚不清楚，为了确定这些患者与前臂血流动力学相关的内皮功能是否与血压正常受试者不同，以及内皮功能是否可以通过持续体育锻炼来改变，我们将原发性高血压患者随机分为一组，每周进行 5 至 7 次 30 分钟的快走，持续 12 周 (n=20) 或不进行任何活动调整的组 (对照组， n=7)。在反应性充血期间使用应变计体积描记法测量前臂血流量，以测试内皮依赖性血管舒张，并在舌下含服硝酸甘油后测量前臂血流量，以测试内皮非依赖性血管舒张。高血压患者反应性充血期间的前臂血流量显着低于血压正常者（n=17）。高血压和正常血压受试者服用硝酸甘油后前臂血流量的增加相似。运动将平均血压从 115.7+/-5.3 降低至 110.2+/-5.1 mmHg (P
The effects of long-term aerobic exercise on endothelial function in patients with essential hypertension remain unclear, To determine whether endothelial function relating to forearm hemodynamics in these patients differs from normotensive subjects and whether endothelial function can be modified by continued physical exercise, we randomized patients with essential hypertension into a group that engaged in 30 minutes of brisk walking 5 to 7 times weekly for 12 weeks (n=20) or a group that underwent no activity modifications (control group, n=7). Forearm blood flow was measured using strain-gauge plethysmography during reactive hyperemia to test for endothelium-dependent vasodilation and after sublingual nitroglycerin administration to test endothelium-independent vasodilation. Forearm blood flow in hypertensive patients during reactive hyperemia was significantly less than that in normotensive subjects (n=17). Increases in forearm blood flow after nitroglycerin were similar between hypertensive and normotensive subjects. Exercise lowered mean blood pressure from 115.7+/-5.3 to 110.2+/-5.1 mmHg (P