Representation of the glomerular olfactory map in the Drosophila brain
Representation of the glomerular olfactory map in the Drosophila brain
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DOI：
10.1016/s0092-8674(02)00700-6
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发表时间：
2002-04-19
期刊：
影响因子：
64.5
通讯作者：
Luo, LQ
中科院分区：
文献类型：
--
作者：
Marin, EC;Jefferis, GSXE;Luo, LQ
我们探究了果蝇触角叶中的气味图谱是如何在更高的嗅觉中枢——蘑菇体和侧角中呈现的。对将树突伸向触角叶中特定小球的投射神经元（PNs）进行系统的单细胞追踪，揭示了它们在侧角中的定型轴突分支模式和终末区域。具有相似轴突终末区域的投射神经元往往接收来自相邻小球的输入。仅根据其轴突投射模式就可以准确预测单个投射神经元的小球类别。这些模式的总和在更高的嗅觉中枢中定义了一个“轴突图谱”，反映了哪些嗅觉受体提供输入。该图谱的特征是投射神经元轴突的空间汇聚和发散，从而实现嗅觉信息的整合。
We explored how the odor map in the Drosophila antennal lobe is represented in higher olfactory centers, the mushroom body and lateral horn. Systematic single-cell tracing of projection neurons (PNs) that send dendrites to specific glomeruli in the antennal lobe revealed their stereotypical axon branching patterns and terminal fields in the lateral horn. PNs with similar axon terminal fields tend to receive input from neighboring glomeruli. The glomerular classes of individual PNs could be accurately predicted based solely on their axon projection patterns. The sum of these patterns defines an "axon map" in higher olfactory centers reflecting which olfactory receptors provide input. This map is characterized by spatial convergence and divergence of PN axons, allowing integration of olfactory information.