Identifying the immunomodulatory components of helminths
Identifying the immunomodulatory components of helminths
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DOI：
10.1111/pim.12192
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发表时间：
2015-06
影响因子：
2.2
通讯作者：
Catherine Shepherd;S. Navarro;P. Wangchuk;David T. Wilson;N. Daly;A. Loukas
中科院分区：
文献类型：
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作者：
Catherine Shepherd;S. Navarro;P. Wangchuk;David T. Wilson;N. Daly;A. Loukas
蠕虫的免疫调节成分为治疗炎症性疾病提供了一种全新的生物制品。在这里，我们在治疗性药物发现的背景下讨论蠕虫驱动的免疫调节的新兴主题。我们广泛定义了目前研究人员用来识别这些蠕虫分子的方法，强调了到目前为止大多数被忽视的潜在开发的关键领域，特别是小分子。最后，我们认为，免疫调节化合物的研究将使当前和未来的研究努力能够转化为自身免疫和过敏性疾病的潜在治疗方法，同时对宿主-寄生虫生物学的分子界面产生新的见解。
Immunomodulatory components of helminths offer great promise as an entirely new class of biologics for the treatment of inflammatory diseases. Here, we discuss the emerging themes in helminth‐driven immunomodulation in the context of therapeutic drug discovery. We broadly define the approaches that are currently applied by researchers to identify these helminth molecules, highlighting key areas of potential exploitation that have been mostly neglected thus far, notably small molecules. Finally, we propose that the investigation of immunomodulatory compounds will enable the translation of current and future research efforts into potential treatments for autoimmune and allergic diseases, while at the same time yielding new insights into the molecular interface of host–parasite biology.