Epigenetic Regulation of Placental NR3C1: Mechanism Underlying Prenatal Programming of Infant Neurobehavior by Maternal Smoking?
Epigenetic Regulation of Placental NR3C1: Mechanism Underlying Prenatal Programming of Infant Neurobehavior by Maternal Smoking?
复制标题
胎盘 NR3C1 的表观遗传调控：母亲吸烟对婴儿神经行为产前编程的潜在机制？
DOI：
10.1111/cdev.12482
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发表时间：
2016
影响因子：
4.6
通讯作者：
Lester,BarryM
中科院分区：
文献类型：
--
作者：
Stroud,LauraR;Papandonatos,GeorgeD;Salisbury,AmyL;Phipps,MaureenG;Huestis,MarilynA;Niaura,Raymond;Padbury,JamesF;Marsit,CarmenJ;Lester,BarryM
Epigenetic regulation of the placental glucocorticoid receptor gene (NR3C1) was investigated as a mechanism underlying links between maternal smoking during pregnancy (MSDP) and infant neurobehavior in 45 mother–infant pairs (49% MSDP‐exposed; 52% minorities; ages 18–35). The Neonatal Intensive Care Unit (NICU) Network Neurobehavioral Scale was administered 7 times over the 1st postnatal month; methylation of placentalNR3C1was assessed via bisulfite pyrosequencing. Increased placentalNR3C1methylation was associated with increased infant attention and self‐regulation, and decreased lethargy and need for examiner soothing over the 1st postnatal month. A causal steps approach revealed thatNR3C1methylation and MSDP were independently associated with lethargic behavior. Although preliminary, results highlight the importance of epigenetic mechanisms in elucidating pathways to neurobehavioral alterations from MSDP.
