Contribution of oncoproteomics to cancer biomarker discovery.
Contribution of oncoproteomics to cancer biomarker discovery.
复制标题
癌组学对癌症生物标志物发现的贡献。
DOI：
10.1186/1476-4598-6-25
复制
发表时间：
2007-04-02
期刊：
影响因子：
37.3
通讯作者：
Cho, William C S
中科院分区：
文献类型：
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作者：
Cho, William C S
癌蛋白质组学是利用蛋白质组学技术研究癌细胞中的蛋白质及其相互作用的科学。蛋白质组学研究最早是随着双向凝胶电泳法的引入而出现的。世纪之交，随着质谱学和蛋白质芯片的广泛引入，蛋白质组学在癌症研究中的应用越来越广泛。应用蛋白质组学来促进对癌症发病机制的更好理解，开发用于诊断的新的肿瘤生物标记物，以及利用样本的蛋白质组学画像进行早期检测，是人们强烈的兴趣。癌蛋白质组学有可能彻底改变临床实践，包括基于蛋白质组平台的癌症诊断和筛查，作为组织病理学的补充，针对整个癌症特异性蛋白质网络的个体化治疗组合的选择，治疗效果和毒性的实时评估，以及基于与预后和耐药性相关的癌症蛋白质网络变化的合理调整治疗。此外，癌蛋白质组学还被应用于新的治疗靶点的发现和药物效应的研究。随着人类基因组计划的圆满完成，蛋白质组学的浪潮拉开了后基因组时代的帷幕。肿瘤蛋白质组学的研究使人类对肿瘤有了更好的了解。本文对近年来发现的肿瘤生物标志物进行了综述。还讨论了癌蛋白质组学在生物标志物开发方面的未来挑战和前景。这篇综述提供了丰富的信息，可应用于广泛的生物标记物研究项目，可供生物标记物研究人员、蛋白质组学和生物信息学科学家、肿瘤学家、制药科学家、生物化学家、生物学家和化学家参考。
Oncoproteomics is the study of proteins and their interactions in a cancer cell by proteomic technologies. Proteomic research first came to the fore with the introduction of two-dimensional gel electrophoresis. At the turn of the century, proteomics has been increasingly applied to cancer research with the wide-spread introduction of mass spectrometry and proteinchip. There is an intense interest in applying proteomics to foster an improved understanding of cancer pathogenesis, develop new tumor biomarkers for diagnosis, and early detection using proteomic portrait of samples. Oncoproteomics has the potential to revolutionize clinical practice, including cancer diagnosis and screening based on proteomic platforms as a complement to histopathology, individualized selection of therapeutic combinations that target the entire cancer-specific protein network, real-time assessment of therapeutic efficacy and toxicity, and rational modulation of therapy based on changes in the cancer protein network associated with prognosis and drug resistance. Besides, oncoproteomics is also applied to the discovery of new therapeutic targets and to the study of drug effects. In pace with the successful completion of the Human Genome Project, the wave of proteomics has raised the curtain on the postgenome era. The study of oncoproteomics provides mankind with a better understanding of neoplasia. In this article, the discovery of cancer biomarkers in recent years is reviewed. The challenges ahead and perspectives of oncoproteomics for biomarkers development are also addressed. With a wealth of information that can be applied to a broad spectrum of biomarker research projects, this review serves as a reference for biomarker researchers, scientists working in proteomics and bioinformatics, oncologists, pharmaceutical scientists, biochemists, biologists, and chemists.