ELECTROLYTE OUTPUT, BLOOD-PRESSURE, AND FAMILY HISTORY OF HYPERTENSION
ELECTROLYTE OUTPUT, BLOOD-PRESSURE, AND FAMILY HISTORY OF HYPERTENSION
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DOI：
10.1093/ajcn/32.5.997
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发表时间：
1979-01-01
影响因子：
7.1
通讯作者：
ALTSCHUL, AM
中科院分区：
文献类型：
--
作者：
PIETINEN, PI;WONG, O;ALTSCHUL, AM
成年正常血压受试者根据其一级亲属是否被诊断为高血压分为两组。在连续3天的24小时内采集尿样，进行电解质排泄分析；过夜时分别测量电解质排泄率。有高血压家族史者的血压与钠、氯排泄、24 h总排泄率和过夜排泄率、Na/K比值、体重和体重指数均呈显著正相关。在无高血压家族史的受试者中，这些参数与血压之间没有显著的相关性。夜间尿钠排泄率可能为进一步研究人群中钠排泄量、血压等参数与高血压家族史之间的关系提供一种手段。
Adult normotensive subjects were divided into 2 groups on the basis of whether their 1st degree relatives were diagnosed as being hypertensive. Urine samples were collected over a 24 h period for 3 days and analyzed for electrolyte excretion; the rate of electrolyte excretion was measured separately during the overnight period. Significant correlations were shown between blood pressure and Na and Cl excretion, both the 24 h total and the overnight rate; Na/K ratio; weight and body mass index for those subjects with a positive family history of hypertension. In subjects with no family history of hypertension, there were no significant correlations between the parameters and blood pressure. The rate of urinary Na excretion overnight may provide a means for further studies on populations to determine the interrelationship between Na excretion, blood pressure, other parameters and family history of hypertension.