Gender differences in motor and non-motor symptoms among Sardinian patients with Parkinson's disease
Gender differences in motor and non-motor symptoms among Sardinian patients with Parkinson's disease
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DOI：
10.1016/j.jns.2012.07.026
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发表时间：
2012-12-15
影响因子：
4.4
通讯作者：
Marrosu, Francesco
中科院分区：
文献类型：
--
作者：
Solla, Paolo;Cannas, Antonino;Marrosu, Francesco
背景资料：帕金森病（PD）在男性中的发生频率高于女性，并且男性发生PD的风险高于女性，这表明性别可能是帕金森综合征发生和进展的重要因素。迄今为止，性别差异在非运动symptoms under-reported.Objective：为了评估性别差异在运动和非运动症状之间撒丁岛PD patients.Methods：一百五十六（91男65女）连续撒丁岛PD门诊患者被纳入本分析。采用改良Hoehn-Yahr量表和运动障碍评定量表（EADS）评定运动症状，采用非运动症状量表（NMSS）评定非运动障碍。抑郁症，焦虑症和其他医源性行为障碍的存在也进行了调查。为探讨帕金森病的性别差异，对132名年龄匹配的正常对照者进行了NMSS评定。结果：女性比男性更容易以震颤为首发症状（P
Background: Parkinson's disease (PD) occurs more frequently in men than in women and a higher risk for PD development in males compared with females has been hypothesized, suggesting gender may be a significant factor in the development and progression of parkinsonism. To date, gender differences in non-motor symptoms are under-reported.Objective: To assess gender differences in motor and non-motor symptoms among Sardinian PD patients.Methods: One hundred fifty-six (91 male and 65 female) consecutive Sardinian PD outpatients were included in this analysis. Modified Hoehn and Yahr scale and UPDRS were used to assess motor symptoms, while non-motor disturbances were evaluated with the non-motor symptoms scale (NMSS). Presence of depression, anxiety and other iatrogenic behavioral disorders was also investigated. In order to determine how gender differences could be specific to PD, 132 age-matched normal controls were assessed with the NMSS.Results: Women were more likely than men to present with tremor as initial symptom (p