D-amphetamine facilitation of Morris water task performance is blocked by eticlopride and correlated with increased dopamine synthesis in the prefrontal cortex
D-amphetamine facilitation of Morris water task performance is blocked by eticlopride and correlated with increased dopamine synthesis in the prefrontal cortex
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DOI：
10.1016/s0166-4328(00)00225-4
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发表时间：
2000-09-01
影响因子：
2.7
通讯作者：
Kraemer, PJ
中科院分区：
文献类型：
--
作者：
Brown, RW;Bardo, MT;Kraemer, PJ
本研究通过每天进行一次训练试验程序训练大鼠，分析了训练后 D-安非他明对莫里斯水任务 (MWT) 表现的影响。除了获取潜伏期之外，还通过最后一次训练试验后 24 小时进行的探索试验来评估学习情况。试验后立即给予 D-苯丙胺的大鼠在采集和探索试验中均表现出比盐水大鼠更好的表现。对促进机制的分析表明，艾氯必利（一种 D2 拮抗剂）阻断了 D-安非他明对探索试验的促进作用，并且相对于对照组，D-安非他明组内侧前额叶皮层的多巴胺合成增加。这些结果表明，训练后长期服用 D-苯丙胺促进了 MWT 表现，并且这种促进可能是由前额皮质中的多巴胺能系统和多巴胺合成介导的。 (C) 2000 Elsevier Science B.V. 保留所有权利。
The effect of posttraining D-amphetamine on Morris water task (MWT) performance was analyzed in this study by training rats using a single training trial per day procedure. In addition to acquisition latency, learning was assessed by a probe trial given 24 h after the last training trial. Rats given immediate post-trial D-amphetamine demonstrated improved performance over saline rats on both acquisition and the probe trial. An analysis of the mechanisms underlying facilitation revealed that eticlopride (a D2 antagonist) blocked D-amphetamine's facilitatory effects on the probe trial and dopamine synthesis was increased in the medial prefrontal cortex in the D-amphetamine group relative to controls. These results show that chronic administration of posttraining D-amphetamine facilitated MWT performance, and this facilitation may be mediated by the dopaminergic system and dopamine synthesis in the prefrontal cortex. (C) 2000 Elsevier Science B.V. All rights reserved.