Computational modeling of RBC and neutrophil transit through the pulmonary capillaries
Computational modeling of RBC and neutrophil transit through the pulmonary capillaries
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DOI：
10.1152/jappl.2001.90.2.545
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发表时间：
2001-02-01
影响因子：
3.3
通讯作者：
Kamm, RD
中科院分区：
文献类型：
--
作者：
Huang, YQ;Doerschuk, CM;Kamm, RD
建立了一个肺微循环的计算模型，并用于研究通过实际复杂的肺泡毛细血管床从小动脉到小静脉的血流。给出了流量、红细胞压积和压力的分布，显示了通过系统的优先路径的存在，以及所有参数在节段之间的巨大差异，证实和扩展了以前的工作。此外，还分析了红细胞(RBC)和中性粒细胞的转运，后者源于之前对白细胞吸入微管的研究。通过时间分布与体内实验很好地一致，特别是表明中性粒细胞相对于红细胞的流动显著减慢，因为需要收缩和延长以适应更窄的毛细血管。预测的中性粒细胞通过时间取决于有效毛细血管直径的定义。中性粒细胞的一过性阻塞可使节段的局部压降增加100-300%，从而导致视频显微镜所见的流量和压力的时间变化。尽管红细胞、中性粒细胞和刚性微球的行为都不同，但所有这些效应都受到经肺压力和小动脉压变化的调节。
A computational model of the pulmonary microcirculation is developed and used to examine blood flow from arteriole to venule through a realistically complex alveolar capillary bed. Distributions of flow, hematocrit, and pressure are presented, showing the existence of preferential pathways through the system and of large segment-to-segment differences in all parameters, confirming and extending previous work. Red blood cell (RBC) and neutrophil transit are also analyzed, the latter drawing from previous studies of leukocyte aspiration into micropipettes. Transit time distributions are in good agreement with in vivo experiments, in particular showing that neutrophils are dramatically slowed relative to the flow of RBCs because of the need to contract and elongate to fit through narrower capillaries. Predicted neutrophil transit times depend on how the effective capillary diameter is defined. Transient blockage by a neutrophil can increase the local pressure drop across a segment by 100-300%, leading to temporal variations in flow and pressure as seen by videomicroscopy. All of these effects are modulated by changes in transpulmonary pressure and arteriolar pressure, although RBCs, neutrophils, and rigid microspheres all behave differently.