Current state of stem cell-based therapies: an overview.
Current state of stem cell-based therapies: an overview.
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DOI：
10.21037/sci-2020-001
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发表时间：
2020-01-01
影响因子：
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通讯作者：
Aly, Riham Mohamed
中科院分区：
文献类型：
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作者：
Aly, Riham Mohamed
最近的研究报告成功地将干细胞疗法转化为患者，这丰富了这种再生策略有朝一日可能成为一种治疗各种棘手疾病的方法的希望。事实上，在过去的几年里，围绕干细胞疗法的临床试验取得了相当大的进展。其中一些试验对各种疾病产生了显着的影响。在这篇综述中，描述了基于干细胞的治疗方法的发展的进展和挑战，重点是在牙科中使用干细胞，除了在几种疾病的再生治疗模式中取得的进展。还讨论了这些治疗的局限性和该领域正在面临的挑战，同时阐明了将基于自体干细胞的干预转化为安全有效的治疗方法的伦理和监管挑战。
Recent research reporting successful translation of stem cell therapies to patients have enriched the hope that such regenerative strategies may one day become a treatment for a wide range of vexing diseases. In fact, the past few years witnessed, a rather exponential advancement in clinical trials revolving around stem cell-based therapies. Some of these trials resulted in remarkable impact on various diseases. In this review, the advances and challenges for the development of stem-cell-based therapies are described, with focus on the use of stem cells in dentistry in addition to the advances reached in regenerative treatment modalities in several diseases. The limitations of these treatments and ongoing challenges in the field are also discussed while shedding light on the ethical and regulatory challenges in translating autologous stem cell-based interventions, into safe and effective therapies.