Iron-Catalyzed C-C Single-Bond Cleavage of Alcohols
Iron-Catalyzed C-C Single-Bond Cleavage of Alcohols
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DOI：
10.1021/acs.orglett.1c03137
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发表时间：
2021-10-12
期刊：
影响因子：
5.2
通讯作者：
Hu, Peng
中科院分区：
文献类型：
--
作者：
Liu, Wei;Wu, Qiang;Hu, Peng
通过光催化，铁催化的C-C键断裂的醇的解构/加氢反应，生成酮或醛。具有广泛取代基的叔醇、仲醇和伯醇是合适的底物。复杂的天然醇也可以选择性地进行转化。机理研究揭示了在2，4，6-Coldine的辅助下，氯自由基促进O-H均解的过程。
An iron-catalyzed deconstruction/hydrogenation reaction of alcohols through C-C bond cleavage is developed through photocatalysis, to produce ketones or aldehydes as the products. Tertiary, secondary, and primary alcohols bearing a wide range of substituents are suitable substrates. Complex natural alcohols can also perform the transformation selectively. A investigation of the mechanism reveals a procedure that involves chlorine radical improved O-H homolysis, with the assistance of 2,4,6-collidine.