High-resolution retinal imaging of cone-rod dystrophy
High-resolution retinal imaging of cone-rod dystrophy
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DOI：
10.1016/j.ophtha.2006.01.056
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发表时间：
2006-06-01
期刊：
影响因子：
13.7
通讯作者：
Williams, DR
中科院分区：
文献类型：
--
作者：
Wolfing, JI;Chung, M;Williams, DR
目的：本研究使用高分辨率自适应光学视网膜成像检查锥-杆营养不良患者。常规检眼镜由于不能克服眼睛的光学像差而提供有限的分辨率。相比之下，自适应光学检眼镜可以纠正这些像差，以提供活体视网膜的非侵入性高分辨率视图。迄今为止，自适应光学检眼镜主要用于检查正常视网膜。在这里，我们使用自适应光学检眼镜成像锥杆营养不良在体内，并比较这些结果与标准的临床试验。设计：观察病例报告。使用罗切斯特大学自适应光学泛光照明检眼镜和休斯顿大学自适应光学扫描激光检眼镜获得锥-杆营养不良患者的高分辨率视网膜图像，并与标准临床试验进行比较，包括眼底照相，Goldmann视野，荧光素血管造影，光学相干断层扫描，视网膜电图，和多焦electroretography.Main结果measurements：直接测量锥密度和直径和比较自适应光学图像与标准的临床成像和功能tests.Results：自适应光学图像采集在多个视网膜位置在整个临床检测到的牛眼病变。在萎缩区域内，我们观察到大面积的波导锥。相比之下，临床检查显示相对不受影响的区域包含完全平铺的锥状镶嵌。然而，在这些区域，视锥细胞异常大，导致正常峰值视锥细胞密度降低6.6倍（患者峰值密度：30 100个视锥细胞/mm（2），正常峰值密度：199 200个视锥细胞/mm（2））。多焦视网膜电图证实中央峰的振幅降低了5.5倍（10.8 novts/degree（2）vs. 59.8 novts/degree（2））。结论：自适应光学检眼镜是一种直接在细胞水平上观察患者视网膜病变的非侵入性技术。它可以提供视网膜疾病中光感受器损失的定量测量。
Purpose: This study examines a patient with cone-rod dystrophy using high-resolution adaptive optics retinal imaging. Conventional ophthalmoscopes provide limited resolution due to their inability to overcome the eye's optical aberrations. In contrast, adaptive optics ophthalmoscopes correct these aberrations to provide noninvasive high-resolution views of the living retina. To date, adaptive optics ophthalmoscopy has been used mainly to examine the normal retina. Here we use adaptive optics ophthalmoscopy to image cone-rod dystrophy in vivo and compare these results with standard clinical tests.Design: Observational case report.Methods: High-resolution retinal images of a patient with cone-rod dystrophy were obtained with the University of Rochester adaptive optics flood-illuminated ophthalmoscope and the adaptive optics scanning laser ophthalmoscope located at the University of Houston and compared with standard clinical tests, including fundus photography, Goldmann visual fields, fluorescein angiography, optical coherence tomography, electroretinography, and multifocal electroretinography.Main Outcome Measures: Direct measurement of cone density and diameter and comparison of adaptive optics images with standard clinical imaging and functional tests.Results: Adaptive optics images were acquired at multiple retinal locations throughout a clinically detected bull's-eye lesion. Within the atrophic regions, we observed large areas devoid of wave-guiding cones. In contrast, regions that appeared relatively spared by clinical examination contained a completely tiled cone mosaic. However, in these areas the cones were abnormally large, resulting in a 6.6-fold reduction from the normal peak cone density (patient peak density: 30 100 cones/mm(2), normal peak density: 199 200 cones/mm(2)). Multifocal electroretinography confirmed a 5.5-fold reduction in amplitude of the central peak (10.8 nanovolts/degree(2) vs. 59.8 nanovolts/degree(2)).Conclusions: Adaptive optics ophthalmoscopy is a noninvasive technique to observe a patient's retinal pathology directly at a cellular level. It can provide a quantitative measurement of photoreceptor loss in retinal disease.