Cavitating pulmonary infiltrate in an adolescent with pyoderma gangrenosum: a rarely recognized extracutaneous manifestation of a neutrophilic dermatosis.
Cavitating pulmonary infiltrate in an adolescent with pyoderma gangrenosum: a rarely recognized extracutaneous manifestation of a neutrophilic dermatosis.
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患有坏疽性脓皮病的青少年出现空洞性肺部浸润：一种罕见的中性粒细胞性皮肤病的皮外表现。
DOI：
10.1067/mjd.2000.103627
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发表时间：
2000
影响因子：
13.8
通讯作者：
J. P. Callen
中科院分区：
文献类型：
--
作者：
Timothy S. Brown;Gary S. Marshall;J. P. Callen
中性粒细胞皮肤病如坏疽性脓疡的特征是无菌的、嗜中性粒细胞的皮肤浸润。皮外嗜中性粒细胞浸润主要发生在关节、肺、心脏、中枢神经系统、胃肠道和眼睛。肺部疾病是坏疽性脓毒症最常报告的皮外表现，其特征为斑片状浸润或间质性肺炎。我们描述了一个典型的坏疽性化脓性脓疡的青少年，他表现为空洞性肺炎，对口服皮质类固醇完全有效。在炎性溃疡患者中，一旦排除感染过程，应考虑皮外嗜酸性疾病。
Neutrophilic dermatoses such as pyoderma gangrenosum are characterized by sterile, neutrophilic cutaneous infiltrates. Extracutaneous neutrophilic infiltrates can occur, primarily in the joints, lungs, heart, central nervous system, gastrointestinal tract, and eyes. Pulmonary disease is the most frequently reported extracutaneous manifestation of pyoderma gangrenosum and is characterized by patchy infiltrates or interstitial pneumonitis. We describe an adolescent with typical pyoderma gangrenosum who presented with cavitary pneumonia and responded completely to oral corticosteroids. In patients with inflammatory ulcers, extracutaneous neutrophilic disease should be considered, once an infectious process has been excluded.