MR image features predicting hemorrhagic transformation in acute cerebral infarction: a multimodal study
MR image features predicting hemorrhagic transformation in acute cerebral infarction: a multimodal study
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DOI：
10.1007/s00234-015-1575-8
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发表时间：
2015-11-01
期刊：
影响因子：
2.8
通讯作者：
Liu, Jun
中科院分区：
文献类型：
--
作者：
Liu, Chunming;Dong, Zhengchao;Liu, Jun
本研究的目的是观察急性脑梗死患者的磁共振成像（MRI）特征和出血性转化（HT）的频率，并确定HT的危险因素。我们首先对87例急性脑梗死患者在症状发作后24小时内进行多模式MRI（解剖，弥散加权和磁敏感加权）扫描，并记录图像结果。然后，我们在发病后3天至2周或患者病情在3天内恶化时进行随访检查。我们利用单变量统计来确定HT和图像特征之间的相关性，并使用多变量逻辑回归来校正混杂因素，以确定HT的相关独立图像特征。在总共87例患者中有17例（19.5%）观察到HT。在单变量统计中，梗死面积（p = 0.021）、脑微出血（CMB）（p = 0.004）、相对表观弥散（rADC）（p = 0.023）和静脉异常（p = 0.000）与HT显著相关。多变量分析表明，（比值比（OR）= 0.082; 95%置信区间（CI）= 0.011-0.597; p = 0.014），rADC（OR = 0.000; 95% CI = 0.000-0.692; p = 0.041）和静脉畸形（OR = 0.066; 95% CI = 0.011-0.403; p = 0.003）是HT的独立危险因素。CMB、rADC和静脉畸形是急性脑梗死HT的独立危险因素。
The aims of this study were to observe magnetic resonance imaging (MRI) features and the frequency of hemorrhagic transformation (HT) in patients with acute cerebral infarction and to identify the risk factors of HT.We first performed multimodal MRI (anatomical, diffusion weighted, and susceptibility weighted) scans on 87 patients with acute cerebral infarction within 24 hours after symptom onset and documented the image findings. We then performed follow-up examinations 3 days to 2 weeks after the onset or whenever the conditions of the patients worsened within 3 days. We utilized univariate statistics to identify the correlations between HT and image features and used multivariate logistical regression to correct for confounding factors to determine relevant independent image features of HT.HT was observed in 17 out of total 87 patients (19.5 %). The infarct size (p = 0.021), cerebral microbleeds (CMBs) (p = 0.004), relative apparent diffusion (rADC) (p = 0.023), and venous anomalies (p = 0.000) were significantly related with HT in the univariate statistics. Multivariate analysis demonstrated that CMBs (odd ratio (OR) = 0.082; 95 % confidence interval (CI) = 0.011-0.597; p = 0.014), rADC (OR = 0.000; 95 % CI = 0.000-0.692; p = 0.041), and venous anomalies (OR = 0.066; 95 % CI = 0.011-0.403; p = 0.003) were independent risk factors for HT.The frequency of HT is 19.5 % in this study. CMBs, rADC, and venous anomalies are independent risk factors for HT of acute cerebral infarction.