Intranodal Lymphangiogenesis Precedes Development of Lymph Node Metastasis and Accelerates Progression of Gastric Cancer
Intranodal Lymphangiogenesis Precedes Development of Lymph Node Metastasis and Accelerates Progression of Gastric Cancer
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DOI：
10.1007/s11605-013-2407-y
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发表时间：
2014-03-01
影响因子：
3.2
通讯作者：
Hirakawa, Kosei
中科院分区：
文献类型：
--
作者：
Watanabe, Mao;Tanaka, Hiroaki;Hirakawa, Kosei
前言在多种肿瘤中，肿瘤周围淋巴管生成与淋巴结转移和预后不良密切相关。然而，关于结内淋巴管生成在淋巴转移中的作用的报道很少。材料与方法采用免疫组织化学方法检测52例胃切除患者1,596个淋巴结中淋巴管密度(LVD)。结果淋巴结内淋巴管密度与胃癌的转移大小及进展密切相关。与低LVD组相比，高LVD组患者的预后更差。此外，结节内淋巴管生成与淋巴结转移和预后不良密切相关。在胃癌中，区域淋巴结中的淋巴管生成在肿瘤细胞通过淋巴系统扩散到远处器官的过程中起着早期作用。
Introduction Peritumoral lymphangiogenesis is significantly correlated with lymph node metastasis and poor prognosis in various cancers. However, there are few reports concerning the role of intranodal lymphangiogenesis in lymphatic metastasis. The aim of this study was to examine the association of lymphangiogenesis in regional lymph nodes with the progression of gastric cancer.Materials and Methods Lymphatic vessel density (LVD) was immunohistochemically estimated in 1,596 lymph nodes from 52 patients who underwent gastrectomy.Results Intranodal LVD was significantly correlated with the size of metastasis and the progression of cancer. Patients in the high LVD group had significantly poorer prognosis relative to patients in the low LVD group. Furthermore, expression of VEGF-C mRNA was significantly up-regulated in lymph nodes of pathological node positive patients compared to node negative patients.Discussion Thus, intranodal lymphangiogenesis was correlated with nodal metastasis and poor prognosis of patients with gastric cancer. Lymphangiogenesis in regional lymph nodes plays an early role in spreading of tumor cells through the lymphatic system to distant organs in gastric cancer.