Skin transcriptome profiling of Changthangi goats highlights the relevance of genes involved in Pashmina production
Skin transcriptome profiling of Changthangi goats highlights the relevance of genes involved in Pashmina production
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DOI：
10.1038/s41598-020-63023-6
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发表时间：
2020-04-08
影响因子：
4.6
通讯作者：
Vijh, Ramesh Kumar
中科院分区：
文献类型：
--
作者：
Ahlawat, Sonika;Arora, Reena;Vijh, Ramesh Kumar
羊绒是世界上最好的天然纤维，来源于查谟和克什米尔拉达克地区游牧牧民驯养的昌丹吉山羊的次级毛囊。复杂的上皮-间充质相互作用涉及许多信号分子和信号通路，它们控制着不同物种的毛囊形态发生和有丝分裂。本研究涉及纤维型Changthangi山羊和肉型Barbari山羊的皮肤转录组分析，以解开可能有助于Pashmina发育的基因网络和代谢途径。在昌德吉山羊中，525个基因表达水平显著较高，54个基因表达水平显著较低，倍数变化>2（p（adj））。
Pashmina, the world's finest natural fiber is derived from secondary hair follicles of Changthangi goats which are domesticated in Ladakh region of Jammu and Kashmir by nomadic pastoralists. Complex epithelial-mesenchymal interactions involving numerous signal molecules and signaling pathways govern hair follicle morphogenesis and mitosis across different species. The present study involved transcriptome profiling of skin from fiber type Changthangi goats and meat type Barbari goats to unravel gene networks and metabolic pathways that might contribute to Pashmina development. In Changthangi goats, 525 genes were expressed at significantly higher levels and 54 at significantly lower levels with fold change >2 (p(adj)