A multicenter pilot study of subcallosal cingulate area deep brain stimulation for treatment-resistant depression
A multicenter pilot study of subcallosal cingulate area deep brain stimulation for treatment-resistant depression
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DOI：
10.3171/2011.10.jns102122
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发表时间：
2012-02-01
影响因子：
4.1
通讯作者：
Mayberg, Helen S.
中科院分区：
文献类型：
--
作者：
Lozano, Andres M.;Giacobbe, Peter;Mayberg, Helen S.
Object.脑深部电刺激（DBS）最近已被研究作为一种治疗重度抑郁症。该应用的拟议目标之一是胼胝体下扣带回（SCG）。迄今为止，单中心报告了SCG DBS后的有希望的结果。在本研究中，作者调查了这些发现是否可以在不同的机构复制。他们对难治性抑郁症患者进行了为期12个月的SCG DBS的3中心前瞻性开放标签试验。21例患者接受了双侧SCG电极植入术。研究者检查了汉密尔顿抑郁量表（HRSD-17）评分较基线（150分）的降低情况。接受SCG DBS治疗的患者在1个月时的平均50为57%，6个月时为48%，12个月时为29%。然而，当定义为基线HRSD-17降低40%或更多时，DBS治疗12个月后的缓解率增加至62%。在对手术有反应的患者中，抑郁性精神障碍的减少与疾病严重程度的改善相关。总体而言，本研究的结果证实了先前报告的结果，表明SCG DBS的结局可在各中心重复。(DOI：10.3171/2011.10.JNS102122）
Object. Deep brain stimulation (DBS) has been recently investigated as a treatment for major depression. One of the proposed targets for this application is the subcallosal cingulate gyms (SCG). To date, promising results after SCG DBS have been reported by a single center. In the present study the authors investigated whether these findings may be replicated at different institutions. They conducted a 3-center prospective open-label trial of SCG DBS for 12 months in patients with treatment-resistant depression.Methods. Twenty-one patients underwent implantation of bilateral SCG electrodes. The authors examined the reduction in Hamilton Rating Scale for Depression (HRSD-17) score from baseline (RESP50).Results. Patients treated with SCG DBS had an RESP50 of 57% at 1 month, 48% at 6 months, and 29% at 12 months. The response rate after 12 months of DBS, however, increased to 62% when defined as a reduction in the baseline HRSD-17 of 40% or more. Reductions in depressive symptomatology were associated with amelioration in disease severity in patients who responded to surgery.Conclusions. Overall, findings from this study corroborate the results of previous reports showing that outcome of SCG DBS may be replicated across centers. (DOI: 10.3171/2011.10.JNS102122)