Uncoupling mitochondrial activity maintains body (V) over dotO2 during hemorrhage-induced O2 deficit in the anesthetized rat
Uncoupling mitochondrial activity maintains body (V) over dotO2 during hemorrhage-induced O2 deficit in the anesthetized rat
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DOI：
10.1016/j.resp.2012.12.006
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发表时间：
2013-03-01
影响因子：
2.3
通讯作者：
Van de Louw, Andry
中科院分区：
文献类型：
--
作者：
Haouzi, Philippe;Van de Louw, Andry
在失血性休克（HS）期间，一旦O-2输送速率（D-O2）下降到“临界水平”以下，O-2摄取（（V）/点（O2））就会下降，这是由线粒体O-2供应减少引起的反应。在麻醉大鼠中，通过缓慢抽取18 ml kg（-1）血液，在20分钟内D-O 2从21.5 ml min（-1）降至2.8 ml min（-1）。这导致（V）相对于点（O2）从6.1 ml min（-1）降低至2.4 ml min（-1）（n=5，p
During a hemorrhagic shock (HS), O-2 uptake ((V) over dot(O2)) decreases as soon as the rate of O-2 delivery (D-O2) drops below a "critical level", a response accounted for by the reduction in mitochondrial O-2 supply. In urethane-anesthetized rats, D-O2 was decreased within 20 min from 21.5 to 2.8 ml min(-1) by slowly withdrawing 18 ml kg(-1) of blood. This led to a reduction in (V) over dot(O2) from 6.1 to 2.4 ml min(-1) (n=5, p