A study of the temporal relationship between plasma high molecular weight angiotensinogen and the development of pregnancy-induced hypertension.
A study of the temporal relationship between plasma high molecular weight angiotensinogen and the development of pregnancy-induced hypertension.
复制标题
血浆高分子量血管紧张素原与妊娠高血压综合征发生时间关系的研究。
DOI：
10.1016/s0895-7061(01)02042-8
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发表时间：
2001
影响因子：
3.2
通讯作者：
Burrill,RE
中科院分区：
文献类型：
--
作者：
Tewksbury,DA;Kaiser,SJ;Burrill,RE
除了通常普遍存在的低分子量血管紧张素原（LMrA）外，在人类妊娠状态中存在显著量的高分子量血管紧张素原（HMrA）。既往研究表明，47%的妊娠高血压综合征（PIH）患者血浆HMrA/LMrA比值显著升高。本研究的目的是确定HMrA/LMrA比值的增加是否先于高血压的发展。从一组妇女在整个怀孕期间收集系列血浆样品。高分子量血管紧张素原和LMrA水平从这些妇女的样本进行了测定。这些妇女中有15人发展为PIH。妊高征组中有7名妇女血浆HMrA/LMrA比值显著升高。HMrA/LMrA比值升高与高血压发病之间无一致性关系。3名妇女在高血压发生前HMrA/LMrA比值升高。在一名妇女的两个事件同时发生，在三名妇女的HMrA/LMrA的比例升高后，高血压的发展。目前的研究表明，妊娠期高血压的发展不是血浆HMrA/LMrA比值升高的主要生物学信号。与胎儿窘迫或胎盘循环系统发育异常相关的其他参数也参与了HMrA/LMrA比值的增加。有人提出，HMrA/LMrA比率的升高是胎盘组织特异性血管紧张素系统减弱的机制。Am J Hypertens 2001;14：794-797 © 2001 American Journal of Hypertension，Ltd.
In addition to the normally prevalent low molecular weight angiotensinogen (LMrA), significant quantities of a high molecular weight angiotensinogen (HMrA) are present in the human pregnant state. Previous studies have documented that 47% of women who develop pregnancy- induced hypertension (PIH) have a significantly elevated plasma HMrA/LMrA ratio. The purpose of this study is to establish whether or not the increase in the HMrA/LMrA ratio precedes the development of hypertension. Serial plasma samples were collected from a group of women throughout their pregnancy. High molecular weight angiotensinogen and LMrA levels in the samples from these women were determined. Fifteen of these women developed PIH. Seven women in the PIH group had a significantly elevated plasma HMrA/LMrA ratio. There was no consistent relationship between the elevation of the HMrA/LMrA ratio and the onset of hypertension. Three women had an elevated HMrA/LMrA ratio before the development of hypertension. In one woman the two events occurred simultaneously, and in three women the HMrA/LMrA ratio was elevated only after the development of hypertension. The current study shows that the development of hypertension during pregnancy is not the primary biologic signal for elevation of the plasma HMrA/LMrA ratio. Other parameters associated with fetal distress or abnormal development of placental circulatory systems must be involved in increasing the HMrA/LMrA ratio. It is proposed that the elevation of the HMrA/LMrA ratio is a mechanism by which the placental tissue specific renin-angiotensin system is attenuated. Am J Hypertens 2001;14:794–797 © 2001 American Journal of Hypertension, Ltd.