An outbreak due to Echovirus type 30 in a neonatal unit in France in 1997:: usefulness of PCR diagnosis
An outbreak due to Echovirus type 30 in a neonatal unit in France in 1997:: usefulness of PCR diagnosis
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DOI：
10.1053/jhin.1999.0634
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发表时间：
1999-09-01
影响因子：
6.9
通讯作者：
Peigue-Lafeuille, H
中科院分区：
文献类型：
--
作者：
Chambon, M;Bailly, JL;Peigue-Lafeuille, H
1997年2月至8月，53名肠道病毒脑膜炎患者在法国克莱蒙费朗住院治疗。除了一人之外，所有人都是孩子。在已确定血清型的病例中，70%涉及ECHO病毒30型。疫情于8月8日停止。两个月后，一名新生儿被送往新生儿病房，被认为是在分娩时感染了ECHO病毒30型脑膜炎。20天后，医院爆发了30型埃科病毒，涉及5名新生儿。其中两人出现脑膜炎，两人出现发热性癫痫；一人无症状。以指示病例毒株为抗原源的中和试验中对产妇血清的回顾检查显示，入院前没有新生儿被动免疫，脑脊液基因组检测使快速诊断成为可能，通过加强卫生措施控制了感染。对新生儿和儿科病房的粪便进行前瞻性检查表明，没有进一步发生这种疾病。在一般人群中未观察到散发病例。因此，在普通人群中，医院感染可能在暴发后很长一段时间内发生；使用分子工具进行快速诊断对于已经住院的患者进行明确诊断和作为快速警报是有用的，即使在季节性疫情之间的间隔也是如此。(C)1999年医院感染学会。
Between February and August 1997, 53 patients with enterovirus meningitis were hospitalized in Clermont-Ferrand, France. All but one were children. Echovirus type 30 was involved in 70% of cases with identified serotype. The outbreak ceased on August 8. Two months later, a neonate was admitted to the neonatal unit with an echovirus type 30 meningitis thought to be acquired at delivery. Twenty days later a nosocomial outbreak of echovirus type 30 involving five neonates occurred. Two of them presented with meningitis and two with febrile seizure; One was asymptomatic. The retrospective examination of the maternal sera in a neutralization test, using the index case strain as a source of antigen, showed that none of the neonates was passively immunized before hospitalization, The use of genome detection in cerebrospinal fluid allowed rapid diagnosis and infection was contained by re-inforcing hygiene measures. Prospective examination of stools in the neonatal and paediatric units showed no further occurrences of the disease. No sporadic case was observed in the general population. Hence, nosocomial infections can occur a long time after an outbreak in the general population; rapid diagnosis With molecular tools is useful both for a definite diagnosis in patients already hospitalized, and to act as a rapid alert, even in intervals between seasonal outbreaks. (C) 1999 The Hospital infection Society.