Influence of respiration on cerebrospinal fluid movement using magnetic resonance spin labeling.
Influence of respiration on cerebrospinal fluid movement using magnetic resonance spin labeling.
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DOI：
10.1186/2045-8118-10-36
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发表时间：
2013-12-27
影响因子：
7.3
通讯作者：
McComb JG
中科院分区：
文献类型：
--
作者：
Yamada S;Miyazaki M;Yamashita Y;Ouyang C;Yui M;Nakahashi M;Shimizu S;Aoki I;Morohoshi Y;McComb JG
磁共振成像 (MRI) 心脏门控相差 (PC) 电影技术已非侵入性地显示了心脏脉冲对脑脊液 (CSF) 运动的影响。平面回波成像 (EPI) 显示脑脊液运动受到心脏搏动和呼吸的影响。此前，还无法以非侵入方式可视化响应呼吸的脑脊液运动。本研究正是为此而进行的。使用具有平衡稳态自由进动 (bSSFP) 读数的非对比时空标记反转脉冲 (Time-SLIP) 研究呼吸对 CSF 运动的影响。在 10 名正常志愿者的颅内室中观察到脑脊液运动响应呼吸。为了阐明呼吸效应，在深吸气、深呼气和屏气开始时触发采集。通过采用这种呼吸诱导的自旋标记 bSSFP 电影方法，我们能够可视化由呼吸偏移引起的脑脊液运动。深吸气时脑脊液向头侧移动（16.4±7.7 毫米），深呼气时向尾部移动（11.6±3.0 毫米）。屏气期间在同一区域观察到小而快速的头侧（3.0±0.4 mm）和尾侧（3.0±0.5 mm）运动，这被认为反映了心脏搏动。 Time-SLIP bSSFP 电影技术可以对与呼吸相关的脑脊液运动进行非侵入性可视化，其程度以前未曾报道过。
Magnetic resonance imaging (MRI) cardiac gated phase contrast (PC) cine techniques have non-invasively shown the effect of the cardiac pulse on cerebrospinal fluid (CSF) movement. Echo planar imaging (EPI) has shown CSF movement as influenced by both cardiac pulsation and respiration. Previously, it has not been possible to visualize CSF movement in response to respiration non-invasively. The present study was undertaken to do so. The effect of respiration on CSF movement was investigated using a non-contrast time-spatial labeling inversion pulse (Time-SLIP) with balanced steady-state free precession (bSSFP) readout. CSF movement was observed in the intracranial compartment in response to respirations in ten normal volunteers. To elucidate the respiration effect, the acquisition was triggered at the beginning of deep inhalation, deep exhalation and breath holding. By employing this respiration-induced spin labeling bSSFP cine method, we were able to visualize CSF movement induced by respiratory excursions. CSF moved cephalad (16.4 ± 7.7 mm) during deep inhalation and caudad (11.6 ± 3.0 mm) during deep exhalation in the prepontine cisternal area. Small but rapid cephalad (3.0 ± 0.4 mm) and caudad (3.0 ± 0.5 mm) movement was observed in the same region during breath holding and is thought to reflect cardiac pulsations. The Time-SLIP bSSFP cine technique allows for non-invasive visualization of CSF movement associated with respiration to a degree not previously reported.