PREDICTION OF RENAL ALLOGRAFT ACUTE REJECTION USING A NOVEL NON-INVASIVE MODEL BASED ON ACOUSTIC RADIATION FORCE IMPULSE
PREDICTION OF RENAL ALLOGRAFT ACUTE REJECTION USING A NOVEL NON-INVASIVE MODEL BASED ON ACOUSTIC RADIATION FORCE IMPULSE
复制标题
使用基于声辐射力脉冲的新型非侵入性模型预测肾同种异体移植物急性排斥反应。
DOI：
10.1016/j.ultrasmedbio.2016.05.003
复制
发表时间：
2016-09-01
影响因子：
2.9
通讯作者：
He, Wanyuan
中科院分区：
文献类型：
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作者：
Yang, Cheng;Jin, Yunjie;He, Wanyuan
基于声辐射力脉冲的点剪切波弹性成像是一种通过测量剪切波速度来量化组织刚度的新技术。共有115例肾移植受者连续入组本前瞻性研究。以移植后1个月为判断急性排斥反应（AR）发生的截止时间，将患者分为两组。AR组的剪切波速度显著高于非AR组。我们创建了一个称为SEV的模型，包括剪切波速度，估计肾小球滤过率和肾脏体积变化，可以成功区分有或没有AR的患者。SEV的受试者工作特征曲线下面积为0.89，高于其他变量的值;在移植后1个月内的患者中甚至更好（0.954），但低于移植后1个月患者的估计肾小球滤过率。因此，SEV模型可以以较高的准确度预测肾移植术后AR，并且在肾移植术后早期可能更有用。(C)2016世界医学与生物学超声联合会。
Point shear wave elastography based on acoustic radiation force impulse is a novel technology used to quantify tissue stiffness by measuring shear wave speed. A total of 115 kidney transplantation recipients were consecutively enrolled in this prospective study. The patients were subdivided into two groups using 1 mo post-transplantation as the cutoff time for determining the development of acute rejection (AR). Shear wave speed was significantly higher in the AR group than in the non-AR group. We created a model called SEV, comprising shear wave speed, estimated glomerular filtration rate and kidney volume change, that could successfully discriminate patients with or without AR. The area under the receiver operating characteristic curve of SEV was 0.89, which was higher than values for other variables; it was even better in patients within 1 mo post-transplantation (0.954), but was lower than the estimated glomerular filtration rate in patients after 1 mo post-transplantation. Therefore, the SEV model may predict AR after renal transplantation with a high degree of accuracy, and it may be more useful in the early post-operative stage after renal transplantation. (C) 2016World Federation for Ultrasound in Medicine & Biology.