Exploiting Specific Interactions toward Next-Generation Polymeric Drug Transporters
Exploiting Specific Interactions toward Next-Generation Polymeric Drug Transporters
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DOI：
10.1021/ja311895z
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发表时间：
2013-02-06
影响因子：
15
通讯作者：
Boerner, Hans G.
中科院分区：
文献类型：
--
作者：
Wieczorek, Sebastian;Krause, Eberhard;Boerner, Hans G.
一种通用方法描述了基于聚合物块肽的聚合物药物载体的高级剪裁。组合方法用于选择合适的肽段来特异性复杂的小分子药物。由此产生的特异性药物制剂使不溶性药物变为水溶性，并能够精确调整超出已建立的嵌段共聚物载体的药物释放谱。虽然氯作为一种部分被批准的光动力癌症治疗药物的原理证明，但这一概念是普遍的，适用于广泛的难治药物。
A generic method describes advanced tailoring of polymer drug carriers based on polymer-block-peptides. Combinatorial means are used to select suitable peptide segments to specifically complex small-molecule drugs. The resulting specific drug formulation agents render insoluble drugs water-soluble and enable precise adjustment of drug-release profiles beyond established block-copolymer carriers. While proof of principle is shown on chlorin as a partially approved drug for photodynamic cancer therapy, the concept is universal and applies to a broad spectrum of difficult drugs.