SOX7 is associated with the suppression of human glioma by HMG-box dependent regulation of Wnt/β-catenin signaling
SOX7 is associated with the suppression of human glioma by HMG-box dependent regulation of Wnt/β-catenin signaling
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SOX7 通过 Wnt/β-连环蛋白信号传导的 HMG 盒依赖性调节与抑制人神经胶质瘤相关。
DOI：
10.1016/j.canlet.2016.02.044
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发表时间：
2016-05-28
期刊：
影响因子：
9.7
通讯作者：
Liu, Xiaoqian
中科院分区：
文献类型：
--
作者：
Zhao, Tianshu;Yang, Hui;Liu, Xiaoqian
SOX 7是一种肿瘤抑制因子，属于SOX（SRY相关HMG盒）转录因子家族。然而，其在人类胶质瘤中的作用尚不清楚。我们的研究表明，SOX 7的表达在人类胶质瘤中显著下调。统计学分析显示，SOX 7抑制与胶质瘤组织中较高的肿瘤组织学分级相关。SOX 7可以抑制体内和体外的肿瘤特性，并且HMG结构域的耗尽消除了其肿瘤抑制作用。体外实验表明，SOX 7能下调Wnt/beta-catenin的转录，降低Cyclin D1和c-Myc的表达，而突变体则丧失了这些功能。这些结果表明，HMG盒是SOX 7的一个关键结构域，在神经胶质瘤中作为肿瘤抑制因子发挥作用时，负调控Wnt/β-连环蛋白信号通路。(C)2016爱思唯尔爱尔兰有限公司版权所有。
SOX7 has been recently recognized as a tumor suppressor belonging to the SOX (SRY-related HMG-box) family of a transcription factor. However, its role in human gliomas is unknown. Our study showed that SOX7 expression was significantly downregulated in human gliomas. Statistical analysis showed that SOX7 suppression was associated with higher histological grades of tumors in glioma tissues. SOX7 could suppress tumor properties both in vivo and in vitro, and depletion of the HMG domain abolishes its tumor suppressive roles. In vitro assays demonstrated that SOX7 could downregulate Wnt/beta-catenin transcription and decrease the expression of Cyclin D1 and c-Myc, while the mutant SOX7 lost these functions. These results suggested that the HMG-box is a key domain of SOX7 for negatively regulating the Wnt/beta-catenin signaling pathway when functioning as a tumor suppressor in a glioma. (C) 2016 Elsevier Ireland Ltd. All rights reserved.