Highly resolved chemical imaging of living cells by using synchrotron infrared microspectrometry
Highly resolved chemical imaging of living cells by using synchrotron infrared microspectrometry
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DOI：
10.1073/pnas.95.9.4837
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发表时间：
1998-04-28
影响因子：
11.1
通讯作者：
Williams, GP
中科院分区：
文献类型：
--
作者：
Jamin, N;Dumas, P;Williams, GP
使用同步辐射作为超亮红外光源，我们已经能够以几微米的空间分辨率绘制单个活细胞内蛋白质，脂质和核酸等官能团的分布。特别是，我们绘制了细胞分裂的最后阶段和坏死期间脂质和蛋白质分布的变化。
Using synchrotron radiation as an ultrabright infrared source, we have been able to map the distributions of functional groups such as proteins, lipids, and nucleic acids inside a single living cell with a spatial resolution of a few microns. In particular, we have mapped the changes in the lipid and protein distributions in both the final stages of cell division and also during necrosis.