Heparan sulfate proteoglycan as a cell-surface endocytosis receptor
Heparan sulfate proteoglycan as a cell-surface endocytosis receptor
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DOI：
10.1016/j.matbio.2013.10.004
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发表时间：
2014-04-01
期刊：
影响因子：
6.9
通讯作者：
Belting, Mattias
中科院分区：
文献类型：
--
作者：
Christianson, Helena C.;Belting, Mattias
各种大分子如何在细胞之间交换以及它们如何进入受体细胞是细胞生物学中具有重要意义的基本问题，例如非病毒药物递送、感染性疾病、代谢紊乱和癌症。硫酸乙酰肝素蛋白聚糖（HSPG）作为多种大分子货物的细胞表面受体的作用最近已被证明。外泌体、细胞穿透肽、聚阳离子-核酸复合物、病毒、脂蛋白、生长因子和形态发生剂以及其他配体通过HSP G介导的内吞作用进入细胞。近年来，部分已被解开的关键问题包括HSPG核心蛋白和HS链结构特异性的大分子货物内吞作用的各自作用，下游的细胞内信号事件参与HSPG依赖的膜内陷和囊泡形成，和HSPG转运途径的生物学意义。在这里，我们讨论了有趣的作用，HSPGs作为一个主要的进入途径的大分子在哺乳动物细胞中，强调最近在体外和体内的数据，提供令人信服的证据，HSPG作为一个自主的内吞受体。(C)2013爱思唯尔有限公司版权所有。
How various macromolecules are exchanged between cells and how they gain entry into recipient cells are fundamental questions in cell biology with important implications e.g. non-viral drug delivery, infectious disease, metabolic disorders, and cancer. The role of heparan sulfate proteoglycan (HSPG) as a cell-surface receptor of diverse macromolecular cargo has recently been manifested. Exosomes, cell penetrating peptides, polycation-nucleic acid complexes, viruses, lipoproteins, growth factors and morphogens among other ligands enter cells through HSPG-mediated endocytosis. Key questions that partially have been unraveled over recent years include the respective roles of HSPG core protein and HS chain structure specificity for macromolecular cargo endocytosis, the down-stream intracellular signaling events involved in HSPG-dependent membrane invagination and vesicle formation, and the biological significance of the HSPG transport pathway. Here, we discuss the intriguing role of HSPGs as a major entry pathway of macromolecules in mammalian cells with emphasis on recent in vitro and in vivo data that provide compelling evidence of HSPG as an autonomous endocytosis receptor. (C) 2013 Elsevier B.V. All rights reserved.