Improved fatigue resistance not associated with maximum oxygen consumption in creatine-depleted rats.
Improved fatigue resistance not associated with maximum oxygen consumption in creatine-depleted rats.
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肌酸耗尽大鼠的抗疲劳能力提高与最大耗氧量无关。
DOI：
10.1152/jappl.1997.82.6.1911
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发表时间：
1997
影响因子：
3.3
通讯作者：
I. Nishi
中科院分区：
文献类型：
--
作者：
T. Tanaka;Y. Ohira;M. Danda;H. Hatta;I. Nishi
研究了肌酸及其类似物β -胍丙酸（β - gpa）饲喂对大鼠耐力、工作能力和耗氧量的影响。与对照组相比，- gpa组后肢肌肉中静息高能磷酸盐含量较低，肌酸组较高。饲喂- gpa的大鼠静息后肢肌肉糖原含量显著高于对照组。与对照组和肌酸组相比，β - gpa组的耐力跑和游泳时间明显增加（32-70%）。然而，β - gpa对大鼠血液最大耗氧量（VO2max）和氧运输能力无显著影响。这些参数均不受肌酸供应的显著影响。β - gpa组的最大运动时间和最大摄氧量均未因糖原水平正常化而改变。β - gpa组骨骼肌线粒体酶活性明显高于对照组。因此，即使肌肉中的高能磷酸盐含量较低，如果肌肉的呼吸能力增加，耐力能力也会得到提高。耐力的增加与肌糖原水平、血液氧运输能力或最大摄氧量的升高没有直接关系。
Effects of feeding of either creatine or its analog beta-guanidinopropionic acid (beta-GPA) on endurance work capacity and oxygen consumption were studied in rats. Resting high-energy phosphate contents in hindlimb muscles were lower in the beta-GPA group and higher in the creatine group than in controls. The glycogen contents in resting hindlimb muscles of rats fed beta-GPA were significantly higher than those in controls. The endurance run and swimming times to exhaustion were significantly greater (32-70%) in the beta-GPA group than in the control and creatine groups. However, there were no beneficial effects on the maximum oxygen consumption (VO2max) and oxygen transport capacity of blood by the feeding of beta-GPA. None of these parameters were significantly influenced by creatine supply. Both maximum exercise time and VO2max in the beta-GPA group were not changed by normalization of glycogen levels. The activities of mitochondrial enzymes in skeletal muscles were higher in the beta-GPA group than in the controls. Thus endurance capacity is improved if the respiratory capacity of muscles is increased, even when the contents of high-energy phosphates in muscles are lower. Increased endurance capacity was not directly associated with the elevated levels of muscle glycogen, oxygen transport capacity of blood, or VO2max.
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肌酸类似物的施用会诱导肌肉中的异肌球蛋白转变。
DOI：
10.1152/ajpcell.1989.257.4.c810
发表时间：
1989
期刊：
The American journal of physiology
影响因子：
--
作者：
Moerland,TS;Wolf,NG;Kushmerick,MJ
通讯作者：
Kushmerick,MJ
DOI：
10.1073/pnas.83.24.9458
发表时间：
1986-12-01
影响因子：
11.1
作者：
CHANCE, B;LEIGH, JS;GRAHAM, T
通讯作者：
GRAHAM, T
缺铁性贫血大鼠的耗氧量和工作能力。
DOI：
10.1093/jn/111.1.17
发表时间：
1981
期刊：
The Journal of nutrition
影响因子：
--
作者：
Ohira,Y;Koziol,BJ;Edgerton,VR;Brooks,GA
通讯作者：
Brooks,GA
大鼠骨骼肌对肌酸消耗的适应：AMP 脱氨酶和 AMP 脱氨。
DOI：
10.1152/jappl.1992.73.6.2713
发表时间：
1992
期刊：
Journal of applied physiology (Bethesda, Md. : 1985)
影响因子：
--
作者：
Ren,JM;Holloszy,JO
通讯作者：
Holloszy,JO