Strategies to Improve the Migration of Mesenchymal Stromal Cells in Cell Therapy
Strategies to Improve the Migration of Mesenchymal Stromal Cells in Cell Therapy
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DOI：
10.18679/cn11-6030_r.2017.025
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发表时间：
2017-09
影响因子：
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通讯作者：
Gaigai Li;Yang Hu;Yanfang Chen;Zhouping Tang
中科院分区：
文献类型：
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作者：
Gaigai Li;Yang Hu;Yanfang Chen;Zhouping Tang
间充质基质/干细胞（MSC）是多能细胞，被认为是一种潜在的新疗法，用于各种炎症性疾病，包括某些神经系统疾病。通常认为，细胞疗法在减轻缺血、炎症或损伤后的损伤中的功效取决于募集到靶组织的移植细胞的量。然而，只有少量系统输注的MSC可以有效地迁移到靶位点，这显著降低了基于外源性细胞的治疗的功效。本文就影响骨髓间充质干细胞迁移的具体因素进行综述，并对目前有效促进骨髓间充质干细胞迁移的策略进行总结。此外，我们描述了几个协议，以改善基质细胞迁移到神经系统，因此，提高移植的效率作为治疗神经系统疾病的手段。
Mesenchymal stromal/stem cells (MSCs) are multipotent cells under consideration as a potential new therapy for a variety of inflammatory diseases including certain neurological disorders. It is generally thought that the efficacy of cell therapy in attenuating damage after ischemia, inflammation, or injury depends on the quantity of transplanted cells recruited to the target tissue. However, only a small number of systematically infused MSCs can effectively migrate to target sites, which significantly decreases the efficacy of exogenous cell-based therapy. In this review, we discuss specific factors influencing MSC migration, and summarize current strategies that effectively promote the motility of MSCs. In addition, we describe several protocols to improve the migration of stromal cells into the nervous system and, therefore, enhance the efficiency of engraftment as means of treating neurological disorders.