Linking Mitochondria and Synaptic Transmission: The CB1 Receptor
Linking Mitochondria and Synaptic Transmission: The CB1 Receptor
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DOI：
10.1002/bies.201700126
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发表时间：
2017-12-01
期刊：
影响因子：
4
通讯作者：
Hebert-Chatelain, Etienne
中科院分区：
文献类型：
--
作者：
Djeungoue-Petga, Marie-Ange;Hebert-Chatelain, Etienne
CB1受体在功能上存在于脑线粒体（mtCB1）中，尽管它们通常被认为是特异性靶向质膜的。急性激活mtCB1改变线粒体ATP生成，突触传递和记忆性能。然而，详细的机制连接中断线粒体代谢和突触传递仍然是未知的。CB1受体是大脑中最丰富的G蛋白偶联受体之一，影响几个过程，包括恐惧应对，焦虑，压力，学习和记忆。线粒体执行神经元稳态的几个关键生理过程，包括ATP和活性氧的产生、钙缓冲、神经递质的代谢和细胞凋亡。因此，mtCB 1的急性激活可能会影响这些不同的线粒体功能以调节突触传递。在回顾和整合这一领域的文献中，我们描述了mtCB1受体调节脑生理学的可能机制。
CB1 receptors are functionally present within brain mitochondria (mtCB1), although they are usually considered specifically targeted to plasma membrane. Acute activation of mtCB1 alters mitochondrial ATP generation, synaptic transmission, and memory performance. However, the detailed mechanism linking disrupted mitochondrial metabolism and synaptic transmission is still uncharacterized. CB1 receptors are among the most abundant G protein-coupled receptors in the brain and impact on several processes, including fear coping, anxiety, stress, learning, and memory. Mitochondria perform several key physiological processes for neuronal homeostasis, including production of ATP and reactive oxygen species, calcium buffering, metabolism of neurotransmitters, and apoptosis. It is therefore possible that acute activation of mtCB1 impacts on these different mitochondrial functions to modulate synaptic transmission. In reviewing and integrating across the literature in this area, we describe the possible mechanisms involved in the regulation of brain physiology by mtCB1 receptors.