Selective activation of CCK-B receptors does not induce sleep and does not affect EEG slow-wave activity and brain temperature in rats.
Selective activation of CCK-B receptors does not induce sleep and does not affect EEG slow-wave activity and brain temperature in rats.
复制标题
选择性激活CCK-B受体不会诱导睡眠，也不影响大鼠脑电图慢波活动和脑温度。
DOI：
10.1016/s0031-9384(97)00034-6
复制
发表时间：
1997
影响因子：
2.9
通讯作者：
Kapás,L
中科院分区：
文献类型：
--
作者：
Chang,HY;Kapás,L
Chang, H.-Y. and L. Kapás. Selective activation of CCK-B receptors does not induce sleep and does not affect EEG slow-wave activity and brain temperature in rats. Physiol Behav 62(1) 175–179, 1997.—Systemic injections of cholecystokinin octapeptide sulfate ester (CCK-8-SE) elicit various behavioral and autonomic responses, such as increases in nonrapid-eye-movement sleep (NREMS) and hypothermia. There are two CCK receptors; both CCK-A and CCK-B receptors are stimulated by CCK-8-SE. The relative importance of the CCK-A and CCK-B receptors in the somnogenic and hypothermic effects of CCK-8-SE is not well understood. In the present experiments, we studied the effects of the selective activation of CCK-B receptors by CCK tetrapeptide (CCK-4) or nonsulfated CCK-8 (CCK-8-NS) on sleep and brain temperature (Tbr). Rats were injected intraperitoneally with saline on the control day and with CCK-8-NS (10, 50, or 250 μg/kg) or CCK-4 (10, 50, or 250 μg/kg) on the test day 5–10 min before dark onset. Electroencephalogram, electromyogram, and Tbrwere recorded for 12 h. None of the treatments affected sleep or Tbrsignificantly, with the exception of 10 μg/kg CCK-4, which transiently decreased the amount of NREMS, and 10 μg/kg CCK-8-NS, which slightly increased REMS. These results suggest that the activation of CCK-B receptors by systemic injection of CCK-4 or CCK-8-NS is not sufficient to elicit increased NREMS and hypothermia in rats.
