IFPA Gabor Than Award lecture: Transformation of the spiral arteries in human pregnancy: Key events in the remodelling timeline
IFPA Gabor Than Award lecture: Transformation of the spiral arteries in human pregnancy: Key events in the remodelling timeline
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DOI：
10.1016/j.placenta.2010.11.018
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发表时间：
2011-03-01
期刊：
影响因子：
3.8
通讯作者：
Harris, L. K.
中科院分区：
文献类型：
--
作者：
Harris, L. K.
在人类怀孕期间，子宫螺旋动脉逐渐重塑，形成缺乏母体血管舒缩控制的扩张导管。这种现象确保了以最佳速度将恒定的血液供应输送到母体-胎儿界面以进行营养交换。将由多层血管平滑肌、弹性蛋白和许多其他细胞外基质成分组成的强直母体小动脉转化为高度扩张但耐用的血管，需要严格的调节控制和多种细胞类型的协调作用。血管壁的初始破坏以内皮细胞损失、血管平滑肌细胞 (VSMC) 分离和错位为特征，与子宫自然杀伤 (uNK) 细胞和巨噬细胞的涌入同时发生。 uNK 细胞是血管生成生长因子和基质降解蛋白酶的来源，因此它们具有引发 VSMC 表型变化并引发细胞外基质分解代谢的能力。然而，血管细胞完全丧失（部分由细胞凋亡和去分化介导）只有在绒毛外滋养层（EVT）在动脉定植后才能实现。 EVT产生多种趋化因子、细胞因子和基质降解蛋白酶，使它们能够影响胎盘床内其他细胞的命运并完成重塑过程。将检查有效血管转化所需的细胞-细胞和细胞-基质相互作用的复杂相互作用，特别关注 (i) uNK 细胞和 (ii) 酶基质金属蛋白酶-12 (MMP-12) 的作用。还将得出与其他血管床中发生的重塑事件的相似之处。 (C) 2011 年由 IFPA 和 Elsevier Ltd 出版。
During human pregnancy, the uterine spiral arteries are progressively remodelled to form dilated conduits lacking maternal vasomotor control. This phenomenon ensures that a constant supply of blood is delivered to the materno-fetal interface at an optimal velocity for nutrient exchange. Conversion of a tonic maternal arteriole composed of multiple layers of vascular smooth muscle, elastin and numerous other extracellular matrix components, into a highly dilated yet durable vessel, requires tight regulatory control and the coordinated actions of multiple cell types. Initial disruption of the vascular wall, characterised by foci of endothelial cell loss, and separation and misalignment of vascular smooth muscle cells (VSMC), is coincident with an influx of uterine natural killer (uNK) cells and macrophages. uNK cells are a source of angiogenic growth factors and matrix degrading proteases, thus they possess the capacity to initiate changes in VSMC phenotype and instigate extracellular matrix catabolism. However, complete vascular cell loss, mediated in part by apoptosis and dedifferentiation, is only achieved following colonisation of the arteries by extravillous trophoblast (EVT). EVT produce a variety of chemokines, cytokines and matrix degrading proteases, enabling them to influence the fate of other cells within the placental bed and complete the remodelling process. The complex interplay of cell-cell and cell-matrix interactions required for effective vascular transformation will be examined, with a particular focus on the role of (i) uNK cells and (ii) the enzyme matrix metalloproteinase-12 (MMP-12). Parallels with remodelling events occurring in other vascular beds will also be drawn. (C) 2011 Published by IFPA and Elsevier Ltd.