DRY TAP BONE-MARROW ASPIRATION - CLINICAL-SIGNIFICANCE
DRY TAP BONE-MARROW ASPIRATION - CLINICAL-SIGNIFICANCE
复制标题
DOI：
10.1002/ajh.2830350405
复制
发表时间：
1990-12-01
影响因子：
12.8
通讯作者：
HUMPHRIES, JE
中科院分区：
文献类型：
--
作者：
HUMPHRIES, JE
尝试骨髓抽吸（“干抽”）时未能获得骨髓通常被归咎于技术错误。对 1983 年 1 月 1 日至 1989 年 7 月 1 日期间在弗吉尼亚大学同时进行的骨髓抽吸和活检的所有报告进行了审查，以确定干抽吸的频率、这些病例的诊断和病理结果以及相关的实验室结果。在 2,235 例同时进行的骨髓穿刺和活检中，87 例为干抽（3.9%）。在这 87 例干抽检中，只有 6 例 (6.9%) 显示正常骨髓活检，其中大多数显示明显的骨髓病理学，通常与纤维化或细胞增多或两者兼而有之。这些情况很可能导致无法抽吸骨髓。最常见的诊断是转移癌（17.2%）、慢性粒细胞白血病（14.9%）、特发性骨髓纤维化（13.8%）和毛细胞白血病（10.3%）。在经历干抽的患者中，经常发现外周血有核红细胞、血小板减少和血清乳酸脱氢酶升高。讨论了在这些病例中获得足够骨髓以进行快速诊断的方法。
Failure to obtain bone marrow on attempted marrow aspiration, "dry tap," has commonly been ascribed to faulty technique. All reports of simultaneous marrow aspirations and biopsies performed at the University of Virginia between January 1, 1983, and July 1, 1989, were reviewed to determine the frequency of dry taps, the diagnoses and pathologic findings in these cases, and the associated laboratory findings. Among 2,235 simultaneous bone marrow aspirations and biopsies, 87 were dry taps (3.9%). Of these 87 dry taps, only six (6.9%) showed normal marrow biopsies, wheres the majority showed significant marrow pathology, usually associated with fibrosis, or hypercellularity, or both. These conditions most likely account for the inability to aspirate marrow. The most frequent diagnoses were metastatic carcinoma (17.2%), chronic myelogenous leukemia (14.9%), idiopathic myelofibrosis (13.8%), and hairy cell leukemia (10.3%). The presence of peripheral blood nucleated red blood cells, thrombocytopenia, and elevation of the serum lactate dehydrogenase were frequent findings in patients who experienced dry taps. Methods to obtain sufficient marrow for rapid diagnosis in these cases are discussed.