The need for consensus on delineation and dose constraints of dentofacial structures in paediatric radiotherapy: Outcomes of a SIOP Europe survey.

The need for consensus on delineation and dose constraints of dentofacial structures in paediatric radiotherapy: Outcomes of a SIOP Europe survey.
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DOI:
10.1016/j.ctro.2023.100681
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发表时间:
2023-11
影响因子:
3.1
通讯作者:
Aznar M
Aznar M
中科院分区:
医学3区
文献类型:
--
作者:
Davey A;Pan S;Bryce-Atkinson A;Mandeville H;Janssens GO;Kelly SM;Hol M;Tang V;Davies LSC;Siop-Europe Radiation Oncology Working Group;Aznar M

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52个儿科放射治疗中心对一项牙面结构放射治疗实践调查作出了答复。超过一半的儿科中心在日常实践中至少描绘了一种牙面结构。牙面结构勾画的主要障碍是缺乏轮廓指导。大多数中心(90%)同意轮廓图谱有助于描绘牙面结构。很少有中心实施牙面结构的特定剂量目标。接受头颈部肿瘤放射治疗的儿童经常会出现严重的牙面副作用。尽管如此,在临床实践中缺乏对牙面结构的轮廓和剂量限制的建议。我们报告的调查,旨在了解目前的做法,轮廓和剂量评估,以牙面结构。向欧洲儿科肿瘤学会放射肿瘤学工作组成员以及欧洲、澳大利亚和新西兰的成员附属中心分发了一份数字调查。这些问题侧重于临床实践,旨在建立未来发展的领域。报告了来自27个国家的52个儿科放射治疗中心的结果。52个中心中只有29个常规描绘了一些牙面结构,最常见的是下颌骨(25个中心)、颞下颌关节(22个)、牙列(13个)、眼眶(10个)和上颌骨(8个)。对于大多数骨轮廓,实施了“尽可能低的合理剂量”目标。只有4个中心报告了年龄适应性剂量限制。剂量限制的临床实施的最大障碍首先是缺乏轮廓指导(49/52,94%),其次是描绘耗时(33/52,63%)。大多数受访者谁经常轮廓牙面结构(25/27,90%)同意轮廓图集将有助于划定。常规描绘的牙面结构是罕见的儿科放射治疗。根据调查结果,我们的目标是1)定义一个共识轮廓的牙面结构图谱,2)开发牙面结构的自动轮廓解决方案,以帮助临床实施,和3)进行治疗计划研究,以调查这些结构的轮廓的重要性,规划优化。
52 paediatric radiotherapy centres responded to a dentofacial structures radiotherapy practice survey. Just over half of paediatric centres delineate at least one dentofacial structure in routine practice. The main barrier to delineation of dentofacial structures is lack of contouring guidance. Most centres (90%) agree a contouring atlas would aid delineation of dentofacial structures. Few centres implement specific dose objectives for dentofacial structures. Children receiving radiotherapy for head-and-neck tumours often experience severe dentofacial side effects. Despite this, recommendations for contouring and dose constraints to dentofacial structures are lacking in clinical practice. We report on a survey aiming to understand current practice in contouring and dose assessment to dentofacial structures. A digital survey was distributed to European Society for Paediatric Oncology members of the Radiation Oncology Working Group, and member-affiliated centres in Europe, Australia, and New Zealand. The questions focused on clinical practice and aimed to establish areas for future development. Results from 52 paediatric radiotherapy centres across 27 countries are reported. Only 29/52 centres routinely delineated some dentofacial structures, with the most common being the mandible (25 centres), temporo-mandibular joint (22), dentition (13), orbit (10) and maxillary bone (eight). For most bones contoured, an ‘As Low As Reasonably Achievable’ dose objective was implemented. Only four centres reported age-adapted dose constraints. The largest barrier to clinical implementation of dose constraints was firstly, the lack of contouring guidance (49/52, 94%) and secondly, that delineation is time-consuming (33/52, 63%). Most respondents who routinely contour dentofacial structures (25/27, 90%) agreed a contouring atlas would aid delineation. Routine delineation of dentofacial structures is infrequent in paediatric radiotherapy. Based on survey findings, we aim to 1) define a consensus-contouring atlas for dentofacial structures, 2) develop auto-contouring solutions for dentofacial structures to aid clinical implementation, and 3) carry out treatment planning studies to investigate the importance of delineation of these structures for planning optimisation.
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